Fosmanogepix (APX001) Is Effective in the Treatment of Immunocompromised Mice Infected with Invasive Pulmonary Scedosporiosis or Disseminated Fusariosis.
Aminopyridines
/ blood
Animals
Antifungal Agents
/ blood
Biological Availability
Brain
/ drug effects
Drug Administration Schedule
Drug Combinations
Fusariosis
/ drug therapy
Fusarium
/ drug effects
Half-Life
Humans
Immunocompromised Host
Invasive Fungal Infections
/ drug therapy
Isoxazoles
/ blood
Kidney
/ drug effects
Lung
/ drug effects
Male
Mice
Mice, Inbred ICR
Microbial Sensitivity Tests
Prodrugs
Scedosporium
/ drug effects
Survival Analysis
Triazoles
/ pharmacology
APX001
APX001A
Fusarium
Gwt1
Scedosporium
antifungal
antifungal agents
fosmanogepix
infection model
manogepix
murine
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
21 02 2020
21 02 2020
Historique:
received:
25
08
2019
accepted:
02
12
2019
pubmed:
11
12
2019
medline:
19
12
2020
entrez:
11
12
2019
Statut:
epublish
Résumé
There are limited treatment options for immunosuppressed patients with lethal invasive fungal infections due to
Identifiants
pubmed: 31818813
pii: AAC.01735-19
doi: 10.1128/AAC.01735-19
pmc: PMC7038288
pii:
doi:
Substances chimiques
APX001A
0
Aminopyridines
0
Antifungal Agents
0
Drug Combinations
0
Isoxazoles
0
Prodrugs
0
Triazoles
0
1-aminobenzotriazole
1614-12-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Alkhazraji et al.
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