Window of opportunity clinical trial designs to study cancer metabolism.
Journal
British journal of cancer
ISSN: 1532-1827
Titre abrégé: Br J Cancer
Pays: England
ID NLM: 0370635
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
16
06
2019
accepted:
18
10
2019
revised:
16
10
2019
pubmed:
11
12
2019
medline:
22
7
2020
entrez:
11
12
2019
Statut:
ppublish
Résumé
Window of opportunity trials exploit the 'window' of time after cancer diagnosis, typically prior to initiation of cancer therapy. In recent years this study design has become a more regular feature of drug development, as this 'window' provides an opportunity to carry out a thorough pharmacodynamic assessment of a therapy of interest in tumours that are unperturbed by prior treatment. Many of the first window trials interrogated the bioactivity of drugs being repurposed for cancer treatment, in particular the anti-mitochondrial agent, metformin. In this review, we describe examples of window study designs that have been used to assess drugs that target cancer metabolism with a focus on metformin. In addition, we discuss how window studies may aid the development of molecular metabolic cancer imaging.
Identifiants
pubmed: 31819180
doi: 10.1038/s41416-019-0621-4
pii: 10.1038/s41416-019-0621-4
pmc: PMC6964681
doi:
Substances chimiques
Metformin
9100L32L2N
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
45-51Subventions
Organisme : Cancer Research UK
Pays : United Kingdom
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