Retinal oxygen supply shaped the functional evolution of the vertebrate eye.
capillaries
evolutionary biology
haemoglobin
vertebrate
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
10 12 2019
10 12 2019
Historique:
received:
23
09
2019
accepted:
19
11
2019
entrez:
11
12
2019
pubmed:
11
12
2019
medline:
8
5
2020
Statut:
epublish
Résumé
The retina has a very high energy demand but lacks an internal blood supply in most vertebrates. Here we explore the hypothesis that oxygen diffusion limited the evolution of retinal morphology by reconstructing the evolution of retinal thickness and the various mechanisms for retinal oxygen supply, including capillarization and acid-induced haemoglobin oxygen unloading. We show that a common ancestor of bony fishes likely had a thin retina without additional retinal oxygen supply mechanisms and that three different types of retinal capillaries were gained and lost independently multiple times during the radiation of vertebrates, and that these were invariably associated with parallel changes in retinal thickness. Since retinal thickness confers multiple advantages to vision, we propose that insufficient retinal oxygen supply constrained the functional evolution of the eye in early vertebrates, and that recurrent origins of additional retinal oxygen supply mechanisms facilitated the phenotypic evolution of improved functional eye morphology.
Identifiants
pubmed: 31820735
doi: 10.7554/eLife.52153
pii: 52153
pmc: PMC6904217
doi:
pii:
Substances chimiques
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Danida Fellowship Centre
ID : DFC no. 12-014AU
Pays : International
Organisme : Carlsbergfondet
ID : CF16-0713
Pays : International
Organisme : Carlsbergfondet
ID : CF17-0195
Pays : International
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBSRC 26/S17991
Pays : United Kingdom
Organisme : National Science Foundation
ID : Office of Polar Programs NSF/PLR OPP-1444167
Pays : International
Organisme : National Science Foundation
ID : Office of Polar Programs NSF/PLR OPP-1543383
Pays : International
Informations de copyright
© 2019, Damsgaard et al.
Déclaration de conflit d'intérêts
CD, HL, AF, JT, TD, DC, PM, DH, NP, HD, AB, HW, EW, TW, JN, MB, MB No competing interests declared
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