Adenosine Metabolism: Emerging Concepts for Cancer Therapy.
adenosine
adenosine kinase
adenosine receptors
biochemistry
cancer
epigenetics
immune checkpoint
intracellular
metabolism
therapy
Journal
Cancer cell
ISSN: 1878-3686
Titre abrégé: Cancer Cell
Pays: United States
ID NLM: 101130617
Informations de publication
Date de publication:
09 12 2019
09 12 2019
Historique:
received:
24
06
2019
revised:
23
08
2019
accepted:
18
10
2019
entrez:
11
12
2019
pubmed:
11
12
2019
medline:
28
5
2020
Statut:
ppublish
Résumé
Adenosine is a key metabolic and immune-checkpoint regulator implicated in the tumor escape from the host immune system. Major gaps in knowledge that impede the development of effective adenosine-based therapeutics include: (1) lack of consideration of redundant pathways controlling ATP and adenosine levels; (2) lack of distinction between receptor-dependent and -independent effects of adenosine, and (3) focus on extracellular adenosine without consideration of intracellular metabolism and compartmentalization. In light of current clinical trials, we provide an overview of adenosine metabolism and point out the need for a more careful evaluation of the entire purinome in emerging cancer therapies.
Identifiants
pubmed: 31821783
pii: S1535-6108(19)30481-7
doi: 10.1016/j.ccell.2019.10.007
pmc: PMC7224341
mid: NIHMS1542036
pii:
doi:
Substances chimiques
Adenosine Triphosphate
8L70Q75FXE
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
582-596Subventions
Organisme : NINDS NIH HHS
ID : R01 NS065957
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103740
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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