Parent-of-origin differences in DNA methylation of X chromosome genes in T lymphocytes.

X chromosome autoimmunity global DNA methylation parental imprinting sex differences

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
26 Dec 2019
Historique:
pubmed: 12 12 2019
medline: 12 12 2019
entrez: 12 12 2019
Statut: ppublish

Résumé

Many autoimmune diseases are more frequent in females than in males in humans and their mouse models, and sex differences in immune responses have been shown. Despite extensive studies of sex hormones, mechanisms underlying these sex differences remain unclear. Here, we focused on sex chromosomes using the "four core genotypes" model in C57BL/6 mice and discovered that the transcriptomes of both autoantigen and anti-CD3/CD28 stimulated CD4

Identifiants

DOI: 10.1073/pnas.1910072116 PMID: 31822606 PMC: PMC6936674
pubmed: 31822606
pii: 1910072116
doi: 10.1073/pnas.1910072116
pmc: PMC6936674
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

26779-26787

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD076125
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS096748
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109670
Pays : United States

Auteurs

Lisa C Golden (LC)

Department of Neurology, University of California, Los Angeles, CA 90095.
Molecular Biology Institute, University of California, Los Angeles, CA 90095.

Yuichiro Itoh (Y)

Department of Neurology, University of California, Los Angeles, CA 90095.

Noriko Itoh (N)

Department of Neurology, University of California, Los Angeles, CA 90095.

Sonia Iyengar (S)

Department of Neurology, University of California, Los Angeles, CA 90095.

Patrick Coit (P)

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109.

Youstina Salama (Y)

Department of Neurology, University of California, Los Angeles, CA 90095.

Arthur P Arnold (AP)

Department of Integrative Biology and Physiology, Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA 90095.

Amr H Sawalha (AH)

Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109.
Center for Computation Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109.

Rhonda R Voskuhl (RR)

Department of Neurology, University of California, Los Angeles, CA 90095.

Classifications MeSH