Microtubule binding kinetics of membrane-bound kinesin-1 predicts high motor copy numbers on intracellular cargo.
diffusion
kinesin-1
kinetics
lipid bilayers
long-range transport
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
26 Dec 2019
26 Dec 2019
Historique:
pubmed:
12
12
2019
medline:
12
12
2019
entrez:
12
12
2019
Statut:
ppublish
Résumé
Bidirectional vesicle transport along microtubules is necessary for cell viability and function, particularly in neurons. When multiple motors are attached to a vesicle, the distance a vesicle travels before dissociating is determined by the race between detachment of the bound motors and attachment of the unbound motors. Motor detachment rate constants (
Identifiants
pubmed: 31822619
pii: 1916204116
doi: 10.1073/pnas.1916204116
pmc: PMC6936695
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
26564-26570Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM121679
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM108563
Pays : United States