A change in the zinc ion concentration reflects the maturation of insulin-producing cells generated from adipose-derived mesenchymal stem cells.
Adipocytes
/ drug effects
Animals
Bone Marrow Cells
/ cytology
Cell Differentiation
/ drug effects
Cells, Cultured
Diabetes Mellitus, Experimental
/ therapy
Dithizone
Glucose
/ pharmacology
Humans
Insulin
/ metabolism
Insulin-Secreting Cells
/ drug effects
Mesenchymal Stem Cells
/ metabolism
Streptozocin
/ pharmacology
Zinc
/ metabolism
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 12 2019
10 12 2019
Historique:
received:
18
07
2019
accepted:
25
11
2019
entrez:
12
12
2019
pubmed:
12
12
2019
medline:
24
11
2020
Statut:
epublish
Résumé
The generation of insulin-producing cells (IPCs) from pluripotent stem cells could be a breakthrough treatment for type 1 diabetes. However, development of new techniques is needed to exclude immature cells for clinical application. Dithizone staining is used to evaluate IPCs by detecting zinc. We hypothesised that zinc ion (Zn
Identifiants
pubmed: 31822724
doi: 10.1038/s41598-019-55172-0
pii: 10.1038/s41598-019-55172-0
pmc: PMC6904733
doi:
Substances chimiques
Insulin
0
Streptozocin
5W494URQ81
Dithizone
60-10-6
Glucose
IY9XDZ35W2
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
18731Références
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