Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study.
Aged
Aged, 80 and over
Aminolevulinic Acid
/ administration & dosage
Angiography
Carcinoma, Basal Cell
/ blood supply
Cohort Studies
Face
/ blood supply
Female
Humans
Male
Middle Aged
Necrosis
Photochemotherapy
Photosensitizing Agents
/ administration & dosage
Skin
/ pathology
Skin Neoplasms
/ blood supply
Tomography, Optical Coherence
Treatment Outcome
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 12 2019
10 12 2019
Historique:
received:
24
07
2019
accepted:
26
11
2019
entrez:
12
12
2019
pubmed:
12
12
2019
medline:
2
12
2020
Statut:
epublish
Résumé
Microvascular networks of human basal cell carcinomas (BCC) and surrounding skin were assessed with optical coherence angiography (OCA) in conjunction with photodynamic therapy (PDT). OCA images were collected and analyzed in 31 lesions pre-treatment, and immediately/24 hours/3-12 months post-treatment. Pre-treatment OCA enabled differentiation between prevalent subtypes of BCC (nodular and superficial) and nodular-with-necrotic-core BCC subtypes with a diagnostic accuracy of 78%; this can facilitate more accurate biopsy reducing sampling error and better therapy regimen selection. Post-treatment OCA images at 24 hours were 98% predictive of eventual outcome. Additional findings highlight the importance of pre-treatment necrotic core, vascular metrics associated with hypertrophic scar formation, and early microvascular changes necessary in both tumorous and peri-tumorous regions to ensure treatment success.
Identifiants
pubmed: 31822752
doi: 10.1038/s41598-019-55215-6
pii: 10.1038/s41598-019-55215-6
pmc: PMC6904495
doi:
Substances chimiques
Photosensitizing Agents
0
Aminolevulinic Acid
88755TAZ87
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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