Modulation of Glycine Receptor-Mediated Pain Signaling

glucose modulation glycinergic transmission hotplate assay nociception pain-related behavior patch-clamp recording spinal α3 glycine receptors tactile sensitivity

Journal

Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914

Informations de publication

Date de publication:
2019
Historique:
received: 24 07 2019
accepted: 01 11 2019
entrez: 12 12 2019
pubmed: 12 12 2019
medline: 12 12 2019
Statut: epublish

Résumé

The inhibitory glycine receptor (GlyR) plays an important role in rapid synaptic inhibition in mammalian spinal cord, brainstem, higher brain centers, and is involved in transmission of nociceptive signals. Glucose and related mono- and disaccharides potentiate currents mediated by recombinant α1, α1-β, and α3 GlyRs. Here, we confirmed the specific potentiation of α3 GlyR signaling by glucose through: (i) patch-clamp electrophysiology on recombinant receptors; and (ii) by verifying

Identifiants

pubmed: 31824259
doi: 10.3389/fnmol.2019.00280
pmc: PMC6883931
doi:

Types de publication

Journal Article

Langues

eng

Pagination

280

Informations de copyright

Copyright © 2019 Hussein, Ahmed, Breitinger and Breitinger.

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Auteurs

Rama Ashraf Hussein (RA)

Department of Biochemistry, German University in Cairo, New Cairo, Egypt.

Marwa Ahmed (M)

Department of Biochemistry, German University in Cairo, New Cairo, Egypt.

Hans-Georg Breitinger (HG)

Department of Biochemistry, German University in Cairo, New Cairo, Egypt.

Ulrike Breitinger (U)

Department of Biochemistry, German University in Cairo, New Cairo, Egypt.

Classifications MeSH