The Effects of Positive End-Expiratory Pressure on Transpulmonary Pressure and Recruitment-Derecruitment During Neurally Adjusted Ventilator Assist: A Continuous Computed Tomography Study in an Animal Model of Acute Respiratory Distress Syndrome.
ARDS
NAVA
PEEP
VILI
mechanical ventilation
respiratory failure
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2019
2019
Historique:
received:
19
07
2019
accepted:
28
10
2019
entrez:
12
12
2019
pubmed:
12
12
2019
medline:
12
12
2019
Statut:
epublish
Résumé
Whether spontaneous breathing (SB) should be used in early acute respiratory distress syndrome (ARDS) is questioned because it may cause ventilator-induced lung injury (VILI) by tidal high strain/stress and recruitment/derecruitment (R/D). However, SB has shown beneficial effects when used appropriately. We hypothesized that high levels of positive end-expiratory pressure (PEEP), during assisted SB, would prevent tidal R/D, reducing ventilatory variation and respiratory rate while potentially increasing transpulmonary pressure ( Mild experimental ARDS (PaO When increasing PEEP from 0 to 15 cmH This study shows that injurious phenomena like R/D and high
Sections du résumé
BACKGROUND
BACKGROUND
Whether spontaneous breathing (SB) should be used in early acute respiratory distress syndrome (ARDS) is questioned because it may cause ventilator-induced lung injury (VILI) by tidal high strain/stress and recruitment/derecruitment (R/D). However, SB has shown beneficial effects when used appropriately. We hypothesized that high levels of positive end-expiratory pressure (PEEP), during assisted SB, would prevent tidal R/D, reducing ventilatory variation and respiratory rate while potentially increasing transpulmonary pressure (
METHODS
METHODS
Mild experimental ARDS (PaO
RESULTS
RESULTS
When increasing PEEP from 0 to 15 cmH
CONCLUSION
CONCLUSIONS
This study shows that injurious phenomena like R/D and high
Identifiants
pubmed: 31824326
doi: 10.3389/fphys.2019.01392
pmc: PMC6882775
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1392Informations de copyright
Copyright © 2019 Widing, Pellegrini, Larsson and Perchiazzi.
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