Stauffer Syndrome: A Comprehensive Review of the Icteric Variant of the Syndrome.
paraneoplastic hepatopathy
paraneoplastic syndrome
renal cell carcinoma
stauffer syndrome
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
30 Oct 2019
30 Oct 2019
Historique:
entrez:
12
12
2019
pubmed:
12
12
2019
medline:
12
12
2019
Statut:
epublish
Résumé
Stauffer syndrome is a rare paraneoplastic syndrome classically associated with renal cell carcinoma (RCC). This association gave it the historical name of nonmetastatic nephrogenic hepatic dysfunction syndrome without jaundice. It is a syndrome of unclear pathophysiology characterized by a reversible anicteric elevation of liver enzymes, alkaline phosphatase, erythrocyte sedimentation rate (ESR), thrombocytosis, prolongation of prothrombin time, and hepatosplenomegaly in the absence of direct hepatobiliary obstruction or jaundice. A rare atypical variant of this syndrome with jaundice has been recently described in the literature. Thus, it is important to consider both these variants of Stauffer syndrome in the differential diagnosis of unexplained cholestasis in the absence of hepatic metastasis. This may allow early recognition and treatment of an occult malignancy. Herein, we present a comprehensive review of the literature available on the icteric variant of the Stauffer syndrome, outlining its association with various malignancies and the diagnostic challenges it poses. The objective of this review is to help clinicians in its early diagnosis and management.
Identifiants
pubmed: 31824799
doi: 10.7759/cureus.6032
pmc: PMC6886655
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e6032Informations de copyright
Copyright © 2019, Sharma et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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