Osteoporosis in a murine model of postmenopausal lupus.
MRL
Systemic lupus erythematosus
bone mineral density
osteoporosis
postmenopausal
Journal
Lupus
ISSN: 1477-0962
Titre abrégé: Lupus
Pays: England
ID NLM: 9204265
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
pubmed:
12
12
2019
medline:
2
6
2020
entrez:
12
12
2019
Statut:
ppublish
Résumé
Postmenopausal women with systemic lupus erythematosus have an increased risk of osteoporosis and associated fractures. Their increased osteoporosis risk is probably caused by a high level of inflammation, use of glucocorticoids, impaired kidney function, and early menopause as these are known risk factors for osteoporosis. Due to these risk factors and the lack of safe and effective treatments, new therapies for the treatment of osteoporosis in this group of patients are needed. Ovariectomized MRL/ Skeletal parameters were measured in MRL/ Total bone mineral density was reduced in MRL/ Ovariectomized MRL/
Sections du résumé
BACKGROUND/OBJECTIVE
OBJECTIVE
Postmenopausal women with systemic lupus erythematosus have an increased risk of osteoporosis and associated fractures. Their increased osteoporosis risk is probably caused by a high level of inflammation, use of glucocorticoids, impaired kidney function, and early menopause as these are known risk factors for osteoporosis. Due to these risk factors and the lack of safe and effective treatments, new therapies for the treatment of osteoporosis in this group of patients are needed. Ovariectomized MRL/
METHODS
METHODS
Skeletal parameters were measured in MRL/
RESULTS
RESULTS
Total bone mineral density was reduced in MRL/
CONCLUSION
CONCLUSIONS
Ovariectomized MRL/
Identifiants
pubmed: 31825765
doi: 10.1177/0961203319893759
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM