Identification of Novel Loci and New Risk Variant in Known Loci for Colorectal Cancer Risk in East Asians.

Adult Aged Asian People / genetics Case-Control Studies China / epidemiology Chromosomes, Human, Pair 1 / genetics Colorectal Neoplasms / epidemiology Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Humans INDEL Mutation Japan / epidemiology Linkage Disequilibrium Male Middle Aged Polymorphism, Single Nucleotide Republic of Korea / epidemiology Risk Factors

Journal

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608

Informations de publication

Date de publication:
02 2020
Historique:
received: 28 06 2019
revised: 30 09 2019
accepted: 04 12 2019
pubmed: 13 12 2019
medline: 20 1 2021
entrez: 13 12 2019
Statut: ppublish

Résumé

Risk variants identified so far for colorectal cancer explain only a small proportion of familial risk of this cancer, particularly in Asians. We performed a genome-wide association study (GWAS) of colorectal cancer in East Asians, including 23,572 colorectal cancer cases and 48,700 controls. To identify novel risk loci, we selected 60 promising risk variants for replication using data from 58,131 colorectal cancer cases and 67,347 controls of European descent. To identify additional risk variants in known colorectal cancer loci, we performed conditional analyses in East Asians. An indel variant, rs67052019 at 1p13.3, was found to be associated with colorectal cancer risk at In this large GWAS, we identified three novel risk loci and two highly suggestive loci for colorectal cancer risk and provided evidence for potential roles of multiple genes and pathways in the etiology of colorectal cancer. In addition, we showed that additional risk variants exist in many colorectal cancer risk loci identified previously. Our study provides novel data to improve the understanding of the genetic basis for colorectal cancer risk.

Sections du résumé

BACKGROUND
Risk variants identified so far for colorectal cancer explain only a small proportion of familial risk of this cancer, particularly in Asians.
METHODS
We performed a genome-wide association study (GWAS) of colorectal cancer in East Asians, including 23,572 colorectal cancer cases and 48,700 controls. To identify novel risk loci, we selected 60 promising risk variants for replication using data from 58,131 colorectal cancer cases and 67,347 controls of European descent. To identify additional risk variants in known colorectal cancer loci, we performed conditional analyses in East Asians.
RESULTS
An indel variant, rs67052019 at 1p13.3, was found to be associated with colorectal cancer risk at
CONCLUSIONS
In this large GWAS, we identified three novel risk loci and two highly suggestive loci for colorectal cancer risk and provided evidence for potential roles of multiple genes and pathways in the etiology of colorectal cancer. In addition, we showed that additional risk variants exist in many colorectal cancer risk loci identified previously.
IMPACT
Our study provides novel data to improve the understanding of the genetic basis for colorectal cancer risk.

Identifiants

DOI: 10.1158/1055-9965.EPI-19-0755 PMID: 31826910 PMC: PMC7571256
pubmed: 31826910
pii: 1055-9965.EPI-19-0755
doi: 10.1158/1055-9965.EPI-19-0755
pmc: PMC7571256
mid: NIHMS1622552
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

477-486

Subventions

Organisme : NCI NIH HHS
ID : R01 CA067941
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004438
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG004446
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA042182
Pays : United States
Organisme : NHLBI NIH HHS
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Organisme : NCI NIH HHS
ID : R01 CA188214
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197735
Pays : United States
Organisme : Cancer Research UK
ID : C570/A16491
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : U10 CA037429
Pays : United States
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ID : R01 CA114347
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Organisme : NHLBI NIH HHS
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Pays : United States
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ID : P30 CA006973
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ID : K05 CA154337
Pays : United States
Organisme : Cancer Research UK
ID : C8221/A19170
Pays : United Kingdom
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Organisme : Medical Research Council
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Pays : United Kingdom
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Pays : United States
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Informations de copyright

©2019 American Association for Cancer Research.

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Auteurs

Yingchang Lu (Y)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee.

Sun-Seog Kweon (SS)

Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.
Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, South Korea.
ORCID: 0000-0003-2378-8550

Qiuyin Cai (Q)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee.

Chizu Tanikawa (C)

Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Xiao-Ou Shu (XO)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee.

Wei-Hua Jia (WH)

State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.

Yong-Bing Xiang (YB)

State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Jeroen R Huyghe (JR)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
ORCID: 0000-0001-6027-9806

Tabitha A Harrison (TA)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
ORCID: 0000-0002-4173-7530

Jeongseon Kim (J)

Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Gyeonggi-do, South Korea.
ORCID: 0000-0002-0889-2686

Aesun Shin (A)

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul National University Cancer Research Institute, Seoul, Korea.
ORCID: 0000-0002-2217-5624

Dong-Hyun Kim (DH)

Department of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, Korea.
ORCID: 0000-0002-0889-2686

Keitaro Matsuo (K)

Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.
Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
ORCID: 0000-0003-1761-6314

Sun Ha Jee (SH)

Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.

Xingyi Guo (X)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee.

Wanqing Wen (W)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee.

Jiajun Shi (J)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
ORCID: 0000-0001-5194-0009

Bingshan Li (B)

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee.

Nan Wang (N)

General Surgery Department, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.

Min-Ho Shin (MH)

Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.
ORCID: 0000-0002-2217-5624

Hong-Lan Li (HL)

State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Zefang Ren (Z)

School of Public Health, Sun Yat-sen University, Guangzhou, China.

Jae Hwan Oh (JH)

Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Gyeonggi-do, South Korea.

Isao Oze (I)

Department of Social and Preventive Medicine, Hallym University College of Medicine, Okcheon-dong, Korea.
ORCID: 0000-0002-0762-1147

Yoon-Ok Ahn (YO)

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea.

Keum Ji Jung (KJ)

Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.

Jing Gao (J)

State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Yu-Tang Gao (YT)

State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Zhi-Zhong Pan (ZZ)

State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.

Yoichiro Kamatani (Y)

Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Andrew T Chan (AT)

Division of Gastroenterology, and Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Broad Institute of Harvard and MIT, Cambridge, Massachusetts.
Department of Epidemiology, and Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts.

Andrea Gsur (A)

Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria.
ORCID: 0000-0002-9795-1528

Jochen Hampe (J)

Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.

Loic Le Marchand (L)

University of Hawaii Cancer Center, Honolulu, Hawaii.

Li Li (L)

Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio.

Annika Lindblom (A)

Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Victor Moreno (V)

Cancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
ORCID: 0000-0002-2818-5487

Polly A Newcomb (PA)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
School of Public Health, University of Washington, Seattle, Washington.

Kenneth Offit (K)

Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
Department of Medicine, Weill Cornell Medical College, New York, New York.

Paul D P Pharoah (PDP)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.

Franzel J B van Duijnhoven (FJB)

Division of Human Nutrition, Wageningen University and Research, Wageningen, the Netherlands.
ORCID: 0000-0001-8367-2352

Bethany Van Guelpen (B)

Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
ORCID: 0000-0002-9692-101X

Pavel Vodicka (P)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.

Stephanie J Weinstein (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland.
ORCID: 0000-0002-3834-1535

Alicja Wolk (A)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0001-7387-6845

Anna H Wu (AH)

University of Southern California, Preventative Medicine, Los Angeles, California.

Li Hsu (L)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Department of Biostatistics, University of Washington, Seattle, Washington.

Yi-Xin Zeng (YX)

State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.

Jirong Long (J)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee.

Ulrike Peters (U)

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Department of Epidemiology, University of Washington, Seattle, Washington.

Koichi Matsuda (K)

Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan.
ORCID: 0000-0001-7292-2686

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee. wei.zheng@vanderbilt.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Identification of Novel Loci and New Risk...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Identification of Novel Loci and New Risk...
questionsmedicales.fr › Personnes › Asiatiques › Identification of Novel Loci and New Risk...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Identification of Novel Loci and New Risk...
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › Identification of Novel Loci and New Risk...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes de mammifère › Chromosomes humains › Chromosomes humains 1-3 › Chromosomes humains de la paire 1 › Identification of Novel Loci and New Risk...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Identification of Novel Loci and New Risk...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Identification of Novel Loci and New Risk...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Identification of Novel Loci and New Risk...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Identification of Novel Loci and New Risk...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of Novel Loci and New Risk...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Mutation de type INDEL › Identification of Novel Loci and New Risk...
questionsmedicales.fr › Régions géographiques › Iles › Japon › Identification of Novel Loci and New Risk...
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