JC Polyomavirus Infection Reveals Delayed Progression of the Infectious Cycle in Normal Human Astrocytes.
Animals
Antigens, Viral, Tumor
Astrocytes
/ virology
Cell Culture Techniques
/ methods
Cell Line
Disease Models, Animal
Disease Progression
Female
Humans
JC Virus
/ genetics
Leukoencephalopathy, Progressive Multifocal
/ virology
Neuroglia
Polyomavirus Infections
/ virology
Simian virus 40
Viral Proteins
/ genetics
JCPyV
PML
SV40
T antigen
astrocytes
cyclins
polyomavirus
primary cells
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
14 02 2020
14 02 2020
Historique:
received:
08
08
2019
accepted:
01
12
2019
pubmed:
13
12
2019
medline:
22
8
2020
entrez:
13
12
2019
Statut:
epublish
Résumé
JC polyomavirus (JCPyV) infects 50 to 80% of the population and is the causative agent of a fatal demyelinating disease of the central nervous system (CNS). JCPyV presents initially as a persistent infection in the kidneys of healthy people, but during immunosuppression, the virus can reactivate and cause progressive multifocal leukoencephalopathy (PML). Within the CNS, JCPyV predominately targets two cell types, oligodendrocytes and astrocytes. Until recently, the role of astrocytes has been masked by the pathology in the myelin-producing oligodendrocytes, which are lytically destroyed by the virus. To better understand how astrocytes are impacted during JCPyV infection, the temporal regulation and infectious cycle of JCPyV were analyzed in primary normal human astrocytes (NHAs). Previous research to define the molecular mechanisms underlying JCPyV infection has mostly relied on the use of cell culture models, such as SVG-A cells (SVGAs), an immortalized, mixed population of glial cells transformed with simian virus 40 (SV40) T antigen. However, SVGAs present several limitations due to their immortalized characteristics, and NHAs represent an innovative approach to study JCPyV infection
Identifiants
pubmed: 31826993
pii: JVI.01331-19
doi: 10.1128/JVI.01331-19
pmc: PMC7022360
pii:
doi:
Substances chimiques
Antigens, Viral, Tumor
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103423
Pays : United States
Organisme : NIAID NIH HHS
ID : R15 AI144686
Pays : United States
Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2020 American Society for Microbiology.
Références
J Infect Dis. 2010 Jul 15;202(2):184-91
pubmed: 20550458
Blood. 2009 May 14;113(20):4834-40
pubmed: 19264918
J Infect Dis. 2009 Mar 15;199(6):837-46
pubmed: 19434930
Acta Neuropathol. 1965 Nov 18;5(2):215-24
pubmed: 5886201
J Neurooncol. 1990 Feb;8(1):13-22
pubmed: 2156960
FASEB J. 2002 Jun;16(8):869-71
pubmed: 11967234
Nucleic Acids Res. 1993 Apr 25;21(8):1959-64
pubmed: 8388103
J Virol. 2001 Oct;75(20):9687-95
pubmed: 11559801
Acta Neuropathol. 2010 Jan;119(1):7-35
pubmed: 20012068
Virology. 1991 Jan;180(1):306-17
pubmed: 1845827
Gastroenterology. 2005 Jan;128(1):33-42
pubmed: 15633121
Neurosci Lett. 1998 Dec 4;257(3):127-30
pubmed: 9870336
J Virol. 2006 Nov;80(21):10506-13
pubmed: 16928756
J Virol. 2003 Dec;77(24):13214-24
pubmed: 14645578
Nat Neurosci. 2015 Jul;18(7):942-52
pubmed: 26108722
J Virol. 2018 Mar 28;92(8):
pubmed: 29437972
J Virol. 1998 Jul;72(7):5335-42
pubmed: 9620986
PLoS Pathog. 2009 Mar;5(3):e1000363
pubmed: 19325891
J Infect Dis. 2011 Jul 1;204(1):103-14
pubmed: 21628664
J Virol. 1996 Oct;70(10):7004-12
pubmed: 8794345
Clin Microbiol Rev. 2012 Jul;25(3):471-506
pubmed: 22763635
Ann Neurol. 2003 May;53(5):636-46
pubmed: 12730998
Virology. 2012 Jan 20;422(2):235-41
pubmed: 22099377
Front Neurosci. 2015 Apr 07;9:114
pubmed: 25904839
J Virol. 1990 Dec;64(12):5812-22
pubmed: 2173768
Ther Adv Neurol Disord. 2015 Nov;8(6):255-73
pubmed: 26600871
N Engl J Med. 2005 Jul 28;353(4):369-74
pubmed: 15947079
J Virol. 1987 May;61(5):1435-41
pubmed: 3033272
Science. 1965 Jun 11;148(3676):1477-9
pubmed: 14301897
J Neuropathol Exp Neurol. 2008 Apr;67(4):341-54
pubmed: 18379434
Curr Biol. 1999 Jul 1;9(13):680-9
pubmed: 10395539
CNS Neurosci Ther. 2019 Jun;25(6):665-673
pubmed: 30929313
J Neurosci. 2008 Jan 2;28(1):264-78
pubmed: 18171944
F1000Res. 2015 Dec 10;4:
pubmed: 26918152
J Virol. 1990 Mar;64(3):1353-6
pubmed: 2154613
Cleve Clin J Med. 2011 Nov;78 Suppl 2:S8-12
pubmed: 22123935
Science. 1978 Sep 29;201(4362):1246-9
pubmed: 211583
mBio. 2016 Jul 05;7(4):
pubmed: 27381292
J Gen Virol. 2010 Dec;91(Pt 12):3042-52
pubmed: 20826618
Lancet. 1971 Jun 19;1(7712):1257-60
pubmed: 4104715
Front Microbiol. 2019 Apr 17;10:783
pubmed: 31065251
Science. 1973 Aug 17;181(4100):674-6
pubmed: 4353360
J Virol. 2003 Oct;77(19):10638-44
pubmed: 12970448
APMIS. 2013 Aug;121(8):685-727
pubmed: 23781977
Biol Chem. 2017 Jul 26;398(8):839-855
pubmed: 28493815
Methods. 2019 Mar 15;157:106-114
pubmed: 30419335
N Engl J Med. 2012 May 17;366(20):1870-80
pubmed: 22591293
Natl Cancer Inst Monogr. 1979 May;(51):205-8
pubmed: 225669
Cancer Res. 1995 Oct 15;55(20):4651-7
pubmed: 7553644
J Virol. 2018 Mar 14;92(7):
pubmed: 29321332
Proc Natl Acad Sci U S A. 1985 Feb;82(4):1257-61
pubmed: 2983332
Neurology. 2009 Nov 10;73(19):1551-8
pubmed: 19901246
Viruses. 2016 Oct 22;8(10):
pubmed: 27782080
Neuroscientist. 2013 Oct;19(5):442-50
pubmed: 23131748
J Cell Biol. 1991 Oct;115(1):1-17
pubmed: 1717476
J Virol. 2013 Jun;87(11):6221-31
pubmed: 23536657
Cancer Res. 2001 May 15;61(10):4287-93
pubmed: 11358858
J Virol. 2006 Dec;80(24):12079-85
pubmed: 17035332
Lancet Neurol. 2018 May;17(5):467-480
pubmed: 29656742
Nature. 1991 Nov 28;354(6351):278-84
pubmed: 1659663
J Neuroimmune Pharmacol. 2013 Dec;8(5):1303-19
pubmed: 24052414
J Virol. 2004 May;78(9):4884-91
pubmed: 15078969
Virology. 2012 Jun 20;428(1):30-40
pubmed: 22516137
J Clin Microbiol. 1997 Sep;35(9):2288-92
pubmed: 9276404
Genes Dev. 2008 Jun 15;22(12):1677-89
pubmed: 18559482
J Infect Dis. 2011 Mar 1;203(5):578-86
pubmed: 21227915
J Neuropathol Exp Neurol. 1998 Mar;57(3):226-30
pubmed: 9600214
Virology. 1999 Sep 15;262(1):178-89
pubmed: 10489351
PLoS One. 2013 May 20;8(5):e64313
pubmed: 23700470
Annu Rev Med. 2010;61:35-47
pubmed: 19719397
J Virol. 1994 Sep;68(9):5496-508
pubmed: 8057432
J Virol. 2008 Sep;82(17):8896-9
pubmed: 18579595
J Virol. 2002 Sep;76(18):9526-32
pubmed: 12186934
Prog Clin Biol Res. 1983;105:227-37
pubmed: 6304760
J Med Virol. 1995 Nov;47(3):219-25
pubmed: 8551272
Virology. 1993 Dec;197(2):537-48
pubmed: 8249277
Prog Clin Biol Res. 1983;105:223-6
pubmed: 6304759
J Clin Invest. 2014 Dec;124(12):5323-36
pubmed: 25401469
Virology. 2019 Feb;528:198-206
pubmed: 30811999
J Cell Biochem. 1996 Feb;60(2):161-72
pubmed: 8655627
Virology. 1989 Jun;170(2):353-61
pubmed: 2543122
Exp Neurol. 2016 Sep;283(Pt B):541-9
pubmed: 26988764