The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
11 12 2019
11 12 2019
Historique:
received:
22
11
2018
accepted:
13
11
2019
entrez:
13
12
2019
pubmed:
13
12
2019
medline:
12
3
2020
Statut:
epublish
Résumé
Autophagy can degrade cargos with the help of selective autophagy receptors such as p62/SQSTM1, which facilitates the degradation of ubiquitinated cargo. While the process of autophagy has been linked to aging, the impact of selective autophagy in lifespan regulation remains unclear. We have recently shown in Caenorhabditis elegans that transcript levels of sqst-1/p62 increase upon a hormetic heat shock, suggesting a role of SQST-1/p62 in stress response and aging. Here, we find that sqst-1/p62 is required for hormetic benefits of heat shock, including longevity, improved neuronal proteostasis, and autophagy induction. Furthermore, overexpression of SQST-1/p62 is sufficient to induce autophagy in distinct tissues, extend lifespan, and improve the fitness of mutants with defects in proteostasis in an autophagy-dependent manner. Collectively, these findings illustrate that increased expression of a selective autophagy receptor is sufficient to induce autophagy, enhance proteostasis and extend longevity, and demonstrate an important role for sqst-1/p62 in proteotoxic stress responses.
Identifiants
pubmed: 31827090
doi: 10.1038/s41467-019-13540-4
pii: 10.1038/s41467-019-13540-4
pmc: PMC6906454
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5648Subventions
Organisme : NIA NIH HHS
ID : R01 AG038664
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG058038
Pays : United States
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