Transperineal laser ablation for percutaneous treatment of benign prostatic hyperplasia: a feasibility study. Results at 6 and 12 months from a retrospective multi-centric study.


Journal

Prostate cancer and prostatic diseases
ISSN: 1476-5608
Titre abrégé: Prostate Cancer Prostatic Dis
Pays: England
ID NLM: 9815755

Informations de publication

Date de publication:
06 2020
Historique:
received: 30 07 2019
accepted: 28 11 2019
revised: 12 11 2019
pubmed: 13 12 2019
medline: 9 3 2021
entrez: 13 12 2019
Statut: ppublish

Résumé

To investigate the effectiveness and safety of SoracteLite™-transperineal percutaneous laser ablation (TPLA) in the treatment of patients with symptomatic benign prostatic hyperplasia (BPH) at 6 and 12 months follow-up. Patients with urinary symptoms secondary to BPH underwent TPLA under local anesthesia in four centers. Under US guidance, up to four 21G applicators were inserted in the prostatic tissue. Each treatment was performed with diode laser operating at 1064 nm changing the illumination time according to prostate size. The primary end-points of this study were change in IPSS, PVR, Qmax, QoL, and prostatic volume at 6 an 12 months from SoracteLite Analysis was performed on data 160 patients (mean age 69.8 ± 9.6 years) with at least 6 months follow and of 83 patients (mean age 67.9 ± 8.7 years) with at least 12 months follow-up. At 6 months, IPSS improved from 22.5 ± 5.1 to 7.7 ± 3.3 (P < 0.001), PVR from 89.5 ± 84.6 to 27.2 ± 44.5 ml (P < 0.001), Qmax from 8.0 ± 3.8 to 14.3 ± 3.9 ml/s (P < 0.001), QoL from 4.5 ± 1.1 to 1.8 ± 1.0 (P < 0.001), volume from 75.0 ± 32.4 to 60.3 ± 24.5 ml (P < 0.001). At 12 months, IPSS improved from 22.5 ± 4.5 to 7.0 ± 2.9 (P < 0.001), PVR from 71.7 ± 93.9 to 17.8 ± 51.0 ml (P < 0.001), Qmax from 8.6 ± 5.2 to 15.0 ± 4.0 ml/s (P < 0.001), QoL from 4.2 ± 0.6 to 1.6 ± 0.9 (P < 0.001), volume from 87.9 ± 31.6 to 58.8 ± 22.9 ml (P < 0.001). 7/160 (4.3%) grade I and 1/160 (0.6%) grade III complication occurred. SoracteLite™ TPLA allows significant improvement of IPSS, Qol, Qmax, PVR, and reduction of prostatic volume at 6 and 12 months.

Identifiants

pubmed: 31827239
doi: 10.1038/s41391-019-0196-4
pii: 10.1038/s41391-019-0196-4
doi:

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

356-363

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Auteurs

Claudio Maurizio Pacella (CM)

Department of Diagnostic Imaging and Interventional Radiology, Regina Apostolorum Hospital, Via San Francesco 50, 00041 Albano Laziale, Rome, Italy.

Gianluigi Patelli (G)

Department of Diagnostic and Interventional Radiology, ASST Bergamoest, via Paderno 21, 24068, Seriate, Italy.

Gennaro Iapicca (G)

Urology Unit, Santa Rita Clinic, Via Appia, 83042 Atripalda, Avellino, Italy.

Guglielmo Manenti (G)

Department of Diagnostic Imaging and Interventional Radiology, Tor Vergata University, Policlinico Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.

Tommaso Perretta (T)

Department of Diagnostic Imaging and Interventional Radiology, Tor Vergata University, Policlinico Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.

Colleen P Ryan (CP)

Department of Diagnostic Imaging and Interventional Radiology, Tor Vergata University, Policlinico Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.

Renato Esposito (R)

iGRECO Ospedali Riuniti, Piazza Quintieri 1, 87100, Cosenza, Italy.

Giovanni Mauri (G)

Division of Interventional Radiology, European Institute of Oncology, IRCCS, Via Ripamonti 435, 20141, Milan, Italy. giovanni.mauri@ieo.it.
Department of Oncology and Hemato-Oncology, Faculty of Medicine and Surgery University of Milan, Milan, Italy. giovanni.mauri@ieo.it.

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