Association Between Ambient Air Pollution and Elevated Risk of Tuberculosis Development.
ambient air pollution
exposure-response function
population attributable fraction
probabilistic risk assessment
tuberculosis
Journal
Infection and drug resistance
ISSN: 1178-6973
Titre abrégé: Infect Drug Resist
Pays: New Zealand
ID NLM: 101550216
Informations de publication
Date de publication:
2019
2019
Historique:
received:
19
08
2019
accepted:
24
11
2019
entrez:
13
12
2019
pubmed:
13
12
2019
medline:
13
12
2019
Statut:
epublish
Résumé
Broad-scale evidence has shown the significant association between ambient air pollutants and the development of tuberculosis (TB). However, the impact of air quality on the risk of TB in Taiwan is still poorly understood. To develop a probabilistic integrated population-level risk assessment approach for evaluating the contribution of ambient air pollution exposure to the risk of TB development among different regions of Taiwan. A Bayesian-based probabilistic risk assessment model was implemented to link exposure concentrations of various air pollutants quantified in a probabilistic manner with the population-based exposure-response models developed by using an epidemiological investigation. The increment of the risk of TB occurred in a region with a higher level of air pollution, indicating a strong relationship between ambient air pollution exposures and TB incidences. Carbon monoxide (CO) exposure showed the highest population attributable fraction (PAF), followed by nitrogen oxides (NO Our findings provide strong empirical support for the hypothesis and observations from the literature that poor air quality is highly likely to link aetiologically to the risk of TB. Therefore, substantial reductions in CO, NO
Sections du résumé
BACKGROUND
BACKGROUND
Broad-scale evidence has shown the significant association between ambient air pollutants and the development of tuberculosis (TB). However, the impact of air quality on the risk of TB in Taiwan is still poorly understood.
OBJECTIVE
OBJECTIVE
To develop a probabilistic integrated population-level risk assessment approach for evaluating the contribution of ambient air pollution exposure to the risk of TB development among different regions of Taiwan.
MATERIALS AND METHODS
METHODS
A Bayesian-based probabilistic risk assessment model was implemented to link exposure concentrations of various air pollutants quantified in a probabilistic manner with the population-based exposure-response models developed by using an epidemiological investigation.
RESULTS
RESULTS
The increment of the risk of TB occurred in a region with a higher level of air pollution, indicating a strong relationship between ambient air pollution exposures and TB incidences. Carbon monoxide (CO) exposure showed the highest population attributable fraction (PAF), followed by nitrogen oxides (NO
CONCLUSION
CONCLUSIONS
Our findings provide strong empirical support for the hypothesis and observations from the literature that poor air quality is highly likely to link aetiologically to the risk of TB. Therefore, substantial reductions in CO, NO
Identifiants
pubmed: 31827330
doi: 10.2147/IDR.S227823
pii: 227823
pmc: PMC6902850
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3835-3847Informations de copyright
© 2019 Lin et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Environ Sci Technol. 2017 Jul 18;51(14):7759-7774
pubmed: 28677960
PLoS Med. 2016 Oct 25;13(10):e1002152
pubmed: 27780211
Nat Rev Immunol. 2001 Oct;1(1):20-30
pubmed: 11905811
Infect Immun. 2001 Mar;69(3):1847-55
pubmed: 11179363
J Immunol. 2011 Mar 15;186(6):3472-83
pubmed: 21321109
J Med Microbiol. 1998 Oct;47(10):871-7
pubmed: 9788810
Occup Environ Med. 2003 Aug;60(8):612-6
pubmed: 12883027
J Infect. 2006 Feb;52(2):77-85
pubmed: 16216328
Environ Pollut. 2017 Sep;228:408-415
pubmed: 28554030
Public Health. 2013 Mar;127(3):268-74
pubmed: 23453197
J Formos Med Assoc. 2006 May;105(5):363-9
pubmed: 16638645
Gastroenterology. 2001 Nov;121(5):1242-6
pubmed: 11677219
Probl Tuberk Bolezn Legk. 2004;(2):17-22
pubmed: 15137122
Arch Environ Health. 1973 Apr;26(4):202-4
pubmed: 4689797
Environ Health Perspect. 2016 Jun;124(6):761-8
pubmed: 26859438
Int J Tuberc Lung Dis. 2007 Jul;11(7):722-32
pubmed: 17609046
Stat Med. 2007 Jul 30;26(17):3229-39
pubmed: 17309113
Lancet Infect Dis. 2008 Oct;8(10):601-11
pubmed: 18922482
Lancet. 2010 May 22;375(9728):1814-29
pubmed: 20488524
J Bacteriol. 2003 Jan;185(1):142-7
pubmed: 12486050
Exp Lung Res. 2005 May;31(4):405-15
pubmed: 16025921
Exp Lung Res. 2002 Apr-May;28(3):201-17
pubmed: 11936774
Environ Pollut. 2016 Nov;218:1170-1179
pubmed: 27595179
J Formos Med Assoc. 2015 Jun;114(6):484-8
pubmed: 25542769
Pulm Med. 2013;2013:828939
pubmed: 23476764
Int J Environ Health Res. 2014 Apr;24(2):103-12
pubmed: 24387197
Sci Rep. 2018 Nov 27;8(1):17411
pubmed: 30479352
Exp Lung Res. 2002 Sep;28(6):493-506
pubmed: 12217215
Sci Total Environ. 2018 Aug 1;631-632:47-55
pubmed: 29524902
PLoS Med. 2007 Jan;4(1):e20
pubmed: 17227135
Occup Environ Med. 2016 Jan;73(1):56-61
pubmed: 26514394
Trop Med Int Health. 2013 Jan;18(1):101-8
pubmed: 23130953
Korean J Intern Med. 2014 Mar;29(2):183-90
pubmed: 24648801
Environ Health Perspect. 2002 Oct;110 Suppl 5:871-5
pubmed: 12426150
Eur Respir J. 1999 May;13(5):1177-88
pubmed: 10414423