Influence of Repetitive Transcranial Magnetic Stimulation on Human Neurochemistry and Functional Connectivity: A Pilot MRI/MRS Study at 7 T.
GABA
functional connectivity
inhibition
magnetic resonance spectroscopy
motor cortex
non-invasive brain stimulation
repetitive transcranial magnetic stimulation
resting-state functional MRI
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
06
2019
accepted:
06
11
2019
entrez:
13
12
2019
pubmed:
13
12
2019
medline:
13
12
2019
Statut:
epublish
Résumé
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation method commonly used in the disciplines of neuroscience, neurology, and neuropsychiatry to examine or modulate brain function. Low frequency rTMS (e.g., 1 Hz) is associated with a net suppression of cortical excitability, whereas higher frequencies (e.g., 5 Hz) purportedly increase excitability. Magnetic resonance spectroscopy (MRS) and resting-state functional MRI (rsfMRI) allow investigation of neurochemistry and functional connectivity, respectively, and can assess the influence of rTMS in these domains. This pilot study investigated the effects of rTMS on the primary motor cortex using pre and post MRS and rsfMRI assessments at 7 T. Seven right-handed males (age 27 ± 7 y.o.) underwent single-voxel MRS and rsfMRI before and about 30-min after rTMS was administered outside the scanner for 20-min over the primary motor cortex of the left (dominant) hemisphere. All participants received 1-Hz rTMS; one participant additionally received 5-Hz rTMS in a separate session. Concentrations of 17 neurochemicals were quantified in left and right motor cortices. Connectivity metrics included fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo) of both motor cortices, strength of related brain networks, and inter-hemispheric connectivity. The group-analysis revealed few trends (i.e., uncorrected for multiple comparisons), including a mean increase in the concentration of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) after the inhibitory rTMS protocol as compared to baseline in the stimulated (left) motor cortex (+8%,
Identifiants
pubmed: 31827419
doi: 10.3389/fnins.2019.01260
pmc: PMC6890551
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1260Subventions
Organisme : NICHD NIH HHS
ID : K01 HD078484
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS076408
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB015894
Pays : United States
Organisme : NIBIB NIH HHS
ID : P41 EB027061
Pays : United States
Informations de copyright
Copyright © 2019 Gröhn, Gillick, Tkáč, Bednařík, Mascali, Deelchand, Michaeli, Meekins, Leffler-McCabe, MacKinnon, Eberly and Mangia.
Références
Neuroimage. 2017 Apr 1;149:285-294
pubmed: 28130194
Magn Reson Med. 2001 Sep;46(3):451-6
pubmed: 11550235
Neuroimage. 2017 May 15;152:360-370
pubmed: 28284797
Neuroimage. 2017 Apr 15;150:262-269
pubmed: 28254457
J Cereb Blood Flow Metab. 2019 Feb 12;:271678X19831022
pubmed: 30755134
Magn Reson Med. 2011 Apr;65(4):901-10
pubmed: 21413056
Front Hum Neurosci. 2018 Mar 26;12:77
pubmed: 29632477
Brain Stimul. 2010 Apr;3(2):95-118
pubmed: 20633438
Neuroimage. 2004 May;22(1):394-400
pubmed: 15110032
Hum Brain Mapp. 2014 May;35(5):1896-905
pubmed: 23897535
Brain Stimul. 2017 Jan - Feb;10(1):59-64
pubmed: 27615793
Neuroimage. 2013 Oct 15;80:125-43
pubmed: 23702418
Magn Reson Med. 2000 Feb;43(2):319-23
pubmed: 10680699
J Neurosci Methods. 2008 Jul 15;172(1):137-41
pubmed: 18501969
J ECT. 2014 Sep;30(3):242-7
pubmed: 24820947
J Neurosci. 2018 Aug 15;38(33):7327-7336
pubmed: 30030397
NMR Biomed. 2012 Feb;25(2):332-9
pubmed: 21796710
NMR Biomed. 2001 Jun;14(4):260-4
pubmed: 11410943
J Cereb Blood Flow Metab. 2018 Feb;38(2):347-359
pubmed: 28273721
Neuropsychiatr Dis Treat. 2016 Sep 13;12:2273-2278
pubmed: 27695332
Elife. 2015 Sep 18;4:e08789
pubmed: 26381352
Neuroimage. 2014 Jun;93 Pt 1:138-45
pubmed: 24555953
J Cereb Blood Flow Metab. 2012 Aug;32(8):1484-95
pubmed: 22434070
Neurology. 1997 May;48(5):1398-403
pubmed: 9153480
J Cereb Blood Flow Metab. 2015 Mar 31;35(4):601-10
pubmed: 25564236
Brain Stimul. 2014 May-Jun;7(3):372-80
pubmed: 24630849
Neuroimage. 2013 Oct 15;80:105-24
pubmed: 23668970
NMR Biomed. 2018 Apr;31(4):e3890
pubmed: 29442388
Clin Neurophysiol. 2017 Nov;128(11):2318-2329
pubmed: 29040922
Neuroimage. 2009 Jun;46(2):432-46
pubmed: 19233292
J Psychiatry Neurosci. 2016 Apr;41(3):E37-45
pubmed: 26900793
Acad Radiol. 2010 Mar;17(3):277-81
pubmed: 20036585
Magn Reson Med. 2012 Apr;67(4):912-8
pubmed: 22287360
J Psychopharmacol. 2018 May;32(5):497-508
pubmed: 29368979
Brain Stimul. 2017 Jul - Aug;10(4):856-858
pubmed: 28363807
Magn Reson Med. 2006 Feb;55(2):250-7
pubmed: 16402370
Comput Biomed Res. 1996 Jun;29(3):162-73
pubmed: 8812068
J Neurophysiol. 2005 Sep;94(3):1668-75
pubmed: 15872061
Magn Reson Med. 1993 Dec;30(6):672-9
pubmed: 8139448
Front Hum Neurosci. 2014 Jun 27;8:378
pubmed: 25018714
Appl Magn Reson. 2005 Mar;29(1):139-157
pubmed: 20179773
Psychiatry Res Neuroimaging. 2016 Jan 30;247:25-33
pubmed: 26651598
J Neurol Neurosurg Psychiatry. 2019 Mar;90(3):294-301
pubmed: 30467209
Neuroimage. 2014 Oct 1;99:237-43
pubmed: 24904994
J Neurosci Res. 2007 Nov 15;85(15):3340-6
pubmed: 17526022
Neuroimage. 2013 Oct 15;80:144-68
pubmed: 23702415
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Oct 1;34(7):1189-95
pubmed: 20600472
Neuroimage. 2012 Oct 1;62(4):2222-31
pubmed: 22366334
Sci Rep. 2019 Feb 26;9(1):2807
pubmed: 30808895
J Neurosci Res. 2013 Aug;91(8):1076-83
pubmed: 23378234
Nat Neurosci. 2013 Jul;16(7):838-44
pubmed: 23799477
Magn Reson Med. 2009 Oct;62(4):868-79
pubmed: 19591201
Elife. 2014 Mar 25;3:e01465
pubmed: 24668166
Front Psychiatry. 2018 Mar 12;9:76
pubmed: 29593585
J Magn Reson. 1999 Nov;141(1):104-20
pubmed: 10527748
PLoS One. 2018 Aug 29;13(8):e0198053
pubmed: 30157179
Electroencephalogr Clin Neurophysiol. 1998 Jan;108(1):1-16
pubmed: 9474057
Magn Reson Med. 1990 Apr;14(1):26-30
pubmed: 2161984
J Neurophysiol. 2009 Jun;101(6):2872-7
pubmed: 19339458
J Cereb Blood Flow Metab. 2007 May;27(5):1055-63
pubmed: 17033694
Neuroimage. 2005 Jul 1;26(3):839-51
pubmed: 15955494
Brain Connect. 2016 Nov;6(9):669-680
pubmed: 27571276
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Brain Stimul. 2019 Sep - Oct;12(5):1159-1168
pubmed: 30930209
J Cereb Blood Flow Metab. 2009 Mar;29(3):441-63
pubmed: 19002199
Neuroimage. 2014 Apr 15;90:449-68
pubmed: 24389422
Eur J Neurosci. 2003 Jun;17(11):2462-8
pubmed: 12814378
Magn Reson Med. 2006 Jun;55(6):1219-26
pubmed: 16688703
Neuroimage. 2017 Aug 1;156:207-213
pubmed: 28533117
Cereb Cortex. 2016 Aug;26(8):3508-26
pubmed: 27230218
Mov Disord. 2013 Feb;28(2):201-9
pubmed: 23239076
J Neurosci. 2009 Apr 22;29(16):5202-6
pubmed: 19386916
Funct Neurol. 2008 Jul-Sep;23(3):113-22
pubmed: 19152730
Nat Neurosci. 2016 Aug 26;19(9):1175-87
pubmed: 27571196