Dietary Supplementation of the Antioxidant Curcumin Halts Systemic LPS-Induced Neuroinflammation-Associated Neurodegeneration and Memory/Synaptic Impairment via the JNK/NF-

Animals Antioxidants / pharmacology Curcumin / pharmacology Dietary Supplements Inflammation / chemically induced JNK Mitogen-Activated Protein Kinases / genetics Lipopolysaccharides / toxicity Male Memory Disorders / chemically induced NF-kappa B / genetics Neuroprotective Agents / pharmacology Neurotoxicity Syndromes / etiology Proto-Oncogene Proteins c-akt / genetics Rats Rats, Sprague-Dawley Signal Transduction / drug effects Synaptic Transmission / drug effects

Journal

Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826

Informations de publication

Date de publication:
2019
Historique:
received: 27 03 2019
revised: 23 08 2019
accepted: 26 09 2019
entrez: 13 12 2019
pubmed: 13 12 2019
medline: 6 5 2020
Statut: epublish

Résumé

Curcumin is a natural polyphenolic compound widely known to have antioxidant, anti-inflammatory, and antiapoptotic properties. In the present study, we explored the neuroprotective effect of curcumin against lipopolysaccharide- (LPS-) induced reactive oxygen species- (ROS-) mediated neuroinflammation, neurodegeneration, and memory deficits in the adult rat hippocampus via regulation of the JNK/NF-

Identifiants

DOI: 10.1155/2019/7860650 PMID: 31827700 PMC: PMC6885271
pubmed: 31827700
doi: 10.1155/2019/7860650
pmc: PMC6885271
doi:

Substances chimiques

Antioxidants 0
Lipopolysaccharides 0
NF-kappa B 0
Neuroprotective Agents 0
Proto-Oncogene Proteins c-akt EC 2.7.11.1
JNK Mitogen-Activated Protein Kinases EC 2.7.11.24
Curcumin IT942ZTH98

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

7860650

Informations de copyright

Copyright © 2019 Muhammad Sohail Khan et al.

Déclaration de conflit d'intérêts

The authors declared no competing financial interests.

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Auteurs

Muhammad Sohail Khan (MS)

Division of Life Science and Applied Life Science (BK 21), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
ORCID: 0000-0001-5226-4081

Tahir Muhammad (T)

Division of Life Science and Applied Life Science (BK 21), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
ORCID: 0000-0001-5819-1397

Muhammad Ikram (M)

Division of Life Science and Applied Life Science (BK 21), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.

Myeong Ok Kim (MO)

Division of Life Science and Applied Life Science (BK 21), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
ORCID: 0000-0003-4317-1072

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Mitogen-Activated Protein Kinases › JNK Mitogen-Activated Protein Kinases › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Manifestations neurocomportementales › Troubles de la mémoire › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Troubles dus à des produits chimiques › Intoxication › Syndromes neurotoxiques › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Dietary Supplementation of the Antioxidant...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Dietary Supplementation of the Antioxidant...