The metabolome: A key measure for exposome research in epidemiology.
Environmental epidemiology
Exposome
High-resolution exposomics
High-resolution metabolomics
Metabolome-wide association study
Precision medicine
Journal
Current epidemiology reports
ISSN: 2196-2995
Titre abrégé: Curr Epidemiol Rep
Pays: Switzerland
ID NLM: 101626185
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
13
12
2019
pubmed:
13
12
2019
medline:
13
12
2019
Statut:
ppublish
Résumé
Application of omics to study human health has created a new era of opportunities for epidemiology research. However, approaches to characterize exogenous health triggers have largely not leveraged advances in analytical platforms and big data. In this review, we highlight the exposome, which is defined as the cumulative measure of exposure and biological responses across a lifetime as a cornerstone for new epidemiology approaches to study complex and preventable human diseases. While no universal approach exists to measure the entirety of the exposome, use of high-resolution mass spectrometry methods provide distinct advantages over traditional biomonitoring and have provided key advances necessary for exposome research. Application to different study designs and recommendations for combining exposome data with novel data analytic frameworks to study complex interactions of multiple stressors are also discussed. Even though challenges still need to be addressed, advances in methods to characterize the exposome provide exciting new opportunities for epidemiology to support fundamental discoveries to improve public health.
Types de publication
Journal Article
Langues
eng
Pagination
93-103Subventions
Organisme : NIEHS NIH HHS
ID : U2C ES030163
Pays : United States
Organisme : NIEHS NIH HHS
ID : U2C ES026561
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES028903
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES029328
Pays : United States
Organisme : NIH HHS
ID : S10 OD018006
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES023515
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107205
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES019776
Pays : United States
Déclaration de conflit d'intérêts
Compliance with Ethical Standards Conflict of Interest Douglas I. Walker, Damaskini Valvi, Nathaniel Rothman, Qing Lan and Dean P. Jones each declare no potential conflicts of interest. Gary W. Miller serves as Editor in Chief of the journal Toxicological Sciences and does receive renumeration for this, but it does not present a conflict.
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