Innovative Molecular Imaging for Clinical Research, Therapeutic Stratification, and Nosography in Neuroscience.
PET
SPECT
clinical research
molecular imaging
neurology
psychiatry
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2019
2019
Historique:
received:
26
02
2019
accepted:
01
11
2019
entrez:
13
12
2019
pubmed:
13
12
2019
medline:
13
12
2019
Statut:
epublish
Résumé
Over the past few decades, several radiotracers have been developed for neuroimaging applications, especially in PET. Because of their low steric hindrance, PET radionuclides can be used to label molecules that are small enough to cross the blood brain barrier, without modifying their biological properties. As the use of 11C is limited by its short physical half-life (20 min), there has been an increasing focus on developing tracers labeled with 18F for clinical use. The first such tracers allowed cerebral blood flow and glucose metabolism to be measured, and the development of molecular imaging has since enabled to focus more closely on specific targets such as receptors, neurotransmitter transporters, and other proteins. Hence, PET and SPECT biomarkers have become indispensable for innovative clinical research. Currently, the treatment options for a number of pathologies, notably neurodegenerative diseases, remain only supportive and symptomatic. Treatments that slow down or reverse disease progression are therefore the subject of numerous studies, in which molecular imaging is proving to be a powerful tool. PET and SPECT biomarkers already make it possible to diagnose several neurological diseases
Identifiants
pubmed: 31828073
doi: 10.3389/fmed.2019.00268
pmc: PMC6890558
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
268Informations de copyright
Copyright © 2019 Beaurain, Salabert, Ribeiro, Arlicot, Damier, Le Jeune, Demonet and Payoux.
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