Paraneoplastic opsoclonus-myoclonus syndrome as a presentation of high grade serous ovarian cancer.
BRCA2
High grade serous ovarian cancer
Opsoclonus-myoclonus syndrome
Paraneoplastic syndrome
Recurrence
Journal
Gynecologic oncology reports
ISSN: 2352-5789
Titre abrégé: Gynecol Oncol Rep
Pays: Netherlands
ID NLM: 101652231
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
06
08
2019
revised:
09
10
2019
accepted:
13
10
2019
entrez:
13
12
2019
pubmed:
13
12
2019
medline:
13
12
2019
Statut:
epublish
Résumé
Opsoclonus-myoclonus syndrome (OMS) is a rare paraneoplastic disorder that is most often seen in association with pediatric neuroblastoma, breast cancer, small cell lung cancer, and prostate cancer. There are only three previously documented cases relating paraneoplastic OMS to ovarian cancer. We present a unique case of OMS related to a stage IIIC high grade serous ovarian carcinoma in a patient with germline BRCA2 mutation, with ten years of clinical follow up. This case report is presented to document the rare association of OMS with epithelial ovarian cancer. Additionally, in this case, OMS and epithelial cancer were successfully treated with medical therapy alone. This is the first report to our knowledge to document ten years of clinical follow up in this context, and to report that the association may not be evident at the time of ovarian cancer recurrence.
Identifiants
pubmed: 31828196
doi: 10.1016/j.gore.2019.100511
pii: S2352-5789(19)30100-6
pii: 100511
pmc: PMC6889297
doi:
Types de publication
Case Reports
Langues
eng
Pagination
100511Informations de copyright
© 2019 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no conflict of interest related to this case report.
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