Using Genetics to Examine a General Liability to Childhood Psychopathology.
Adolescent
Attention Deficit Disorder with Hyperactivity
/ diagnosis
Autism Spectrum Disorder
/ diagnosis
Child
Cohort Studies
Depression
/ diagnosis
Female
Genetic Predisposition to Disease
/ genetics
Genome-Wide Association Study
/ methods
Humans
Longitudinal Studies
Male
Mental Disorders
/ genetics
Multifactorial Inheritance
/ genetics
Prospective Studies
Psychopathology
/ methods
Risk Factors
Schizophrenia
/ diagnosis
United Kingdom
/ epidemiology
ALSPAC
Childhood
Genetic
Polygenic risk scores
Psychopathology
p-factor
Journal
Behavior genetics
ISSN: 1573-3297
Titre abrégé: Behav Genet
Pays: United States
ID NLM: 0251711
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
24
05
2019
accepted:
22
11
2019
pubmed:
13
12
2019
medline:
8
6
2021
entrez:
13
12
2019
Statut:
ppublish
Résumé
Psychiatric disorders show phenotypic as well as genetic overlaps. There are however also marked developmental changes throughout childhood. We investigated the extent to which, for a full range of early childhood psychopathology, a general "p" factor was explained by genetic liability, as indexed by multiple different psychiatric polygenic risk scores (PRS) and whether these relationships altered with age. The sample was a UK, prospective, population-based cohort with psychopathology data at age 7 (N = 8161) and age 13 (N = 7017). PRS were generated from large published genome-wide association studies. At both ages, we found evidence for a childhood "p" factor as well as for specific factors. Schizophrenia and attention-deficit/hyperactivity disorder (ADHD) PRS were associated with this general "p" factor at both ages but depression and autism spectrum disorder (ASD) PRS were not. We also found some evidence of associations between schizophrenia, ADHD and depression PRS with specific factors, but these were less robust and there was evidence for developmental changes.
Identifiants
pubmed: 31828458
doi: 10.1007/s10519-019-09985-4
pii: 10.1007/s10519-019-09985-4
pmc: PMC7355267
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
213-220Subventions
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106047
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204895/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
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