Assessment of gait parameters and physical function in patients with advanced cancer participating in a 12-week exercise and nutrition programme: A controlled clinical trial.
Adult
Aged
Body Composition
Counseling
Dietary Supplements
Electric Impedance
Electric Stimulation Therapy
Exercise Therapy
/ methods
Female
Gait
Gait Analysis
Gastrointestinal Neoplasms
/ pathology
Genital Neoplasms, Female
/ pathology
Humans
Karnofsky Performance Status
Lung Neoplasms
/ pathology
Male
Middle Aged
Muscle, Skeletal
Neoplasm Staging
Neoplasms
/ pathology
Nutritional Support
Patient Reported Outcome Measures
Physical Functional Performance
Pilot Projects
Quality of Life
Urologic Neoplasms
/ pathology
Walk Test
Walking Speed
cancer
exercise
gait
nutrition
physical function
whole-body electromyostimulation
Journal
European journal of cancer care
ISSN: 1365-2354
Titre abrégé: Eur J Cancer Care (Engl)
Pays: England
ID NLM: 9301979
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
15
01
2019
revised:
12
09
2019
accepted:
22
11
2019
pubmed:
13
12
2019
medline:
5
1
2021
entrez:
13
12
2019
Statut:
ppublish
Résumé
Gait is a sensitive marker for functional declines commonly seen in patients treated for advanced cancer. We tested the effect of a combined exercise and nutrition programme on gait parameters of advanced-stage cancer patients using a novel wearable gait analysis system. Eighty patients were allocated to a control group with nutritional support or to an intervention group additionally receiving whole-body electromyostimulation (WB-EMS) training (2×/week). At baseline and after 12 weeks, physical function was assessed by a biosensor-based gait analysis during a six-minute walk test, a 30-s sit-to-stand test, a hand grip strength test, the Karnofsky Index and EORTC QLQ-C30 questionnaire. Body composition was measured by bioelectrical impedance analysis and inflammation by blood analysis. Final analysis included 41 patients (56.1% male; 60.0 ± 13.0 years). After 12 weeks, the WB-EMS group showed higher stride length, gait velocity (p < .05), six-minute walking distance (p < .01), bodyweight and skeletal muscle mass, and emotional functioning (p < .05) compared with controls. Correlations between changes in gait and in body composition, physical function and inflammation were detected. Whole-body electromyostimulation combined with nutrition may help to improve gait and functional status of cancer patients. Sensor-based mobile gait analysis objectively reflects patients' physical status and could support treatment decisions.
Types de publication
Controlled Clinical Trial
Journal Article
Langues
eng
Pagination
e13199Subventions
Organisme : Forschungsstiftung Medizin at the University Hospital Erlangen
Organisme : Manfred-Roth-Foundation
Organisme : Baxter Germany
Organisme : Bürgerstiftung Erlangen
Organisme : H.W. & J. Hector Foundation
Informations de copyright
© 2019 John Wiley & Sons Ltd.
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