The Role of Vitamin K in Vascular Calcification.
Chronic kidney disease
Matrix Gla protein
Vascular calcification
Vitamin K
Warfarin
Journal
Advances in chronic kidney disease
ISSN: 1548-5609
Titre abrégé: Adv Chronic Kidney Dis
Pays: United States
ID NLM: 101209214
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
30
07
2019
revised:
25
10
2019
accepted:
28
10
2019
entrez:
14
12
2019
pubmed:
14
12
2019
medline:
5
8
2020
Statut:
ppublish
Résumé
Vascular calcification (VC) is common in advanced chronic kidney disease (CKD), contributes to cardiovascular disease (CVD), and associates with increased mortality. Major risk factors for VC in CKD are increasing age, dialysis vintage, and positive net calcium-phosphate balance. To date, no specific therapy that prevents progression or facilitates regression of VC beyond careful attention to calcium and phosphate balance exists. Accumulating evidence demonstrates that CKD patients may incur subclinical vitamin K deficiency. This deficiency may be induced by exhaustion of vitamin K due to its high requirement by vitamin K-dependent proteins to inhibit VC. This review analyzes the pathophysiological mechanisms and clinical consequences of vitamin K deficiency with emphasis on its involvement on vascular calcification in CKD and end-stage renal disease and its relationship to the bone-vascular axis.
Identifiants
pubmed: 31831122
pii: S1548-5595(19)30197-1
doi: 10.1053/j.ackd.2019.10.005
pii:
doi:
Substances chimiques
Vitamin K
12001-79-5
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
437-444Informations de copyright
Copyright © 2019 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.