Peak focusing based on stationary phase thickness gradient.

Alkanes / chemistry Chemistry Techniques, Analytical / methods Chromatography, Gas / instrumentation Temperature
Gas chromatography Peak capacity Peak focusing Resolution Stationary phase gradient Thickness gradient

Journal

Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488

Informations de publication

Date de publication:
15 Mar 2020
Historique:
received: 30 09 2019
revised: 24 11 2019
accepted: 25 11 2019
pubmed: 14 12 2019
medline: 1 5 2020
entrez: 14 12 2019
Statut: ppublish

Résumé

This paper reports the development of a stationary phase thickness gradient gas chromatography (GC) column that enables analyte peak focusing and improves separation resolution. Theoretical analysis and simulation demonstrate focusing via a positive thickness gradient, i.e., the stationary phase thickness increases along the column. This effect was experimentally verified by coating a 5 m long capillary column with a film thickness varying from 34 nm at the column inlet to 241 nm at the column outlet. The column was analyzed in forward (thin to thick) and backward (thick to thin) modes and compared to a uniform thickness column with a thickness of 131 nm, using alkanes ranging from C

Identifiants

DOI: 10.1016/j.chroma.2019.460737 PMID: 31831145
pubmed: 31831145
pii: S0021-9673(19)31169-0
doi: 10.1016/j.chroma.2019.460737
pii:
doi:

Substances chimiques

Alkanes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

460737

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflict of interest.

Auteurs

Maxwell Wei-Hao Li (MW)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Center for Wireless Integrated MicroSensing and Systems (WIMS2), University of Michigan, Ann Arbor, MI 48109, USA; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA.

Hongbo Zhu (H)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Center for Wireless Integrated MicroSensing and Systems (WIMS2), University of Michigan, Ann Arbor, MI 48109, USA.

Menglian Zhou (M)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Center for Wireless Integrated MicroSensing and Systems (WIMS2), University of Michigan, Ann Arbor, MI 48109, USA.

Jinyan She (J)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Center for Wireless Integrated MicroSensing and Systems (WIMS2), University of Michigan, Ann Arbor, MI 48109, USA.

Ziqi Li (Z)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; School of Precision Instruments and Opto-electronics Engineering, Tianjin University, PR China.

Katsuo Kurabayashi (K)

Center for Wireless Integrated MicroSensing and Systems (WIMS2), University of Michigan, Ann Arbor, MI 48109, USA; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Xudong Fan (X)

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Center for Wireless Integrated MicroSensing and Systems (WIMS2), University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: xsfan@umich.edu.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcanes › Peak focusing based on stationary phase...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Peak focusing based on stationary phase...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase gazeuse › Peak focusing based on stationary phase...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Température › Peak focusing based on stationary phase...