Biomechanical and Morphologic Effects of Collagen Cross-Linking in Human Tarsus.
cross-linking
floppy eyelids
tarsus
Journal
Translational vision science & technology
ISSN: 2164-2591
Titre abrégé: Transl Vis Sci Technol
Pays: United States
ID NLM: 101595919
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
21
02
2019
accepted:
03
07
2019
entrez:
14
12
2019
pubmed:
14
12
2019
medline:
14
12
2019
Statut:
epublish
Résumé
To investigate the feasibility of increasing the stiffness of human tarsal tissue following treatment with riboflavin and ultraviolet A (UVA) to induce cross-linking of collagen fibers. In this case control study, 18 right and left upper eyelids were excised en bloc from 18 fresh-frozen cadavers. One side served as the control while the samples from the opposite side were cross-linked. Four 2 × 6-mm vertical strips of central tarsus were cut from the superior to inferior border of each tarsal plate. Sample tissue was irradiated with UVA at 6 mW/cm Mean Young's modulus in the linear region for controls was 28 ± 9 MPa and was much higher at 138 ± 8 MPa for cross-linked samples ( The findings of this study suggest that collagen cross-linking is a viable and effective modality for increasing the stiffness of human tarsal plates. This work provides proof that collagen cross-linking produces stiffening of the human tarsal plate and may be used in disorders that cause eyelid laxity.
Identifiants
pubmed: 31832279
doi: 10.1167/tvst.8.6.25
pii: TVST-19-1458
pmc: PMC6900964
doi:
Types de publication
Journal Article
Langues
eng
Pagination
25Subventions
Organisme : NEI NIH HHS
ID : P30 EY000331
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY008313
Pays : United States
Informations de copyright
Copyright 2019 The Authors.
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