The role of genetics in cognitive remediation in schizophrenia: A systematic review.
5-HT1A-R
BDNF
COMT
Cognitive remediation
EAAT2
Genetics
Journal
Schizophrenia research. Cognition
ISSN: 2215-0013
Titre abrégé: Schizophr Res Cogn
Pays: United States
ID NLM: 101632223
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
31
10
2018
revised:
08
04
2019
accepted:
17
04
2019
entrez:
14
12
2019
pubmed:
14
12
2019
medline:
14
12
2019
Statut:
epublish
Résumé
The role of genetics in cognitive remediation therapies in schizophrenia has not been completely understood yet. Different genes involved in neurotrophic, dopaminergic and serotonin systems have reported to influence cognitive functioning in schizophrenia. These genetic factors could also be contributing to the variability in responsiveness to cognitive treatments. No comprehensive synthesis of the literature of the role of genetics in the context of cognitive remediation has been conducted until now. We aimed to systematically review the published works through three electronic database searches: PubMed, Scopus, and the Cochrane Library. Eligible studies revealed a rising interest in the field although the number of published studies was rather small (n = 10). Eventually, promising results showing a relationship between some phenotypic variations based on different polymorphisms and different levels of responsivity to cognitive remediation therapies have been described although results are still inconclusive. In case those findings will be replicated, they could be guiding future research and informing clinical decision-making in the next future.
Identifiants
pubmed: 31832337
doi: 10.1016/j.scog.2019.100146
pii: S2215-0013(18)30042-8
pii: 100146
pmc: PMC6889757
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100146Informations de copyright
© 2019 The Authors.
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