Metabolic reprogramming of
Krebs cycle
Salmonella
glycolysis
iron
mTOR
macrophage
Journal
Microbial cell (Graz, Austria)
ISSN: 2311-2638
Titre abrégé: Microb Cell
Pays: Austria
ID NLM: 101632887
Informations de publication
Date de publication:
14 Nov 2019
14 Nov 2019
Historique:
entrez:
14
12
2019
pubmed:
14
12
2019
medline:
14
12
2019
Statut:
epublish
Résumé
Iron is an essential nutrient for immune cells and microbes, therefore the control of its homeostasis plays a decisive role for infections. Moreover, iron affects metabolic pathways by modulating the translational expression of the key tricarboxylic acid cycle (TCA) enzyme mitochondrial aconitase and the energy formation by mitochondria. Recent data provide evidence for metabolic re-programming of immune cells including macrophages during infection which is centrally controlled by mTOR. We herein studied the effects of iron perturbations on metabolic profiles in macrophages upon infection with the intracellular bacterium
Identifiants
pubmed: 31832425
doi: 10.15698/mic2019.12.700
pii: MIC0179E125
pmc: PMC6883347
doi:
Types de publication
Journal Article
Langues
eng
Pagination
531-543Subventions
Organisme : Austrian Science Fund FWF
ID : I 3321
Pays : Austria
Déclaration de conflit d'intérêts
Conflict of interest: The authors declare to have no conflict of interest.
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