The Role of Interleukin-4 and 13 Gene Polymorphisms in Allergic Rhinitis: A Case Control Study.

Allergic rhinitis Interleukin 13 Interleukin 4 Single nucleotide polymorphism

Journal

Reports of biochemistry & molecular biology
ISSN: 2322-3480
Titre abrégé: Rep Biochem Mol Biol
Pays: Iran
ID NLM: 101637937

Informations de publication

Date de publication:
Jul 2019
Historique:
entrez: 14 12 2019
pubmed: 14 12 2019
medline: 14 12 2019
Statut: ppublish

Résumé

Allergic Rhinitis (AR) is an IgE-mediated inflammatory disorder with high morbidity rates. The eitiology of this disease is understood to occur from a complex interaction between genetic and environmental factors. T helper type 2 cells have been shown to have a crucial role in atopic disease due to their production of the cytokines, intelukin A case-control study was designed to investigate the relationship between the two SNPs rs2243250 and rs20541 with the incidence of AR. The SNPs were examined in patients with AR and healthy controls (86 patients and 86 controls). Blood samples were collected and DNA was extracted to evaluate the SNPs by RFLP-PCR. Recessive analysis model of the Our findings suggest that the

Sections du résumé

BACKGROUND BACKGROUND
Allergic Rhinitis (AR) is an IgE-mediated inflammatory disorder with high morbidity rates. The eitiology of this disease is understood to occur from a complex interaction between genetic and environmental factors. T helper type 2 cells have been shown to have a crucial role in atopic disease due to their production of the cytokines, intelukin
METHODS METHODS
A case-control study was designed to investigate the relationship between the two SNPs rs2243250 and rs20541 with the incidence of AR. The SNPs were examined in patients with AR and healthy controls (86 patients and 86 controls). Blood samples were collected and DNA was extracted to evaluate the SNPs by RFLP-PCR.
RESULTS RESULTS
Recessive analysis model of the
CONCLUSION CONCLUSIONS
Our findings suggest that the

Identifiants

PMID: 31832433 PMC: PMC6844616
pubmed: 31832433
pmc: PMC6844616

Types de publication

Journal Article

Langues

eng

Pagination

111-118

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Auteurs

Afshin Shirkani (A)

Allergy and Clinical immunology Department, School of Medicine, Bushehr University of Medical Science, Bushehr. Iran.

Atena Mansouri (A)

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.

Reza Farid Hosseini (R)

Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Farahzad Jabbari Azad (F)

Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Reihaneh Alsadat Mahmoudian (R)

Immunology Research Center, Mashhad University of medical Sciences, Mashhad, Iran.

Mehdi Montazer (M)

Department of Pathology Shiraz University of Medical Sciences, Shiraz, Iran.

Abdolreza Samimi (A)

Department of Anesthesiologie and prehospital emergency and intensivmedicine and pain, St. Et. Elisabeth Hospital Dorsten, KKRN, Westfalen Wilhelm University Munster, Germany.

Amir Abbas Momtazi-Borojeni (AA)

Student Research Committee, Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Biotechnology, Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Mohammad Reza Abbaszadegan (MR)

Medical Genetics Research Center, Faculty of Medical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.

Mehran Gholamin (M)

Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.

Classifications MeSH