Differential Effects of Open- and Closed-Loop Intracortical Microstimulation on Firing Patterns of Neurons in Distant Cortical Areas.
anesthesia
electrical stimulation
forelimb
motor cortex
neuronal plasticity
neurons
neurophysiology
rats
somatosensory cortex
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
14 05 2020
14 05 2020
Historique:
received:
11
06
2019
revised:
27
08
2019
accepted:
01
10
2019
pubmed:
14
12
2019
medline:
21
10
2021
entrez:
14
12
2019
Statut:
ppublish
Résumé
Intracortical microstimulation can be used successfully to modulate neuronal activity. Activity-dependent stimulation (ADS), in which action potentials recorded extracellularly from a single neuron are used to trigger stimulation at another cortical location (closed-loop), is an effective treatment for behavioral recovery after brain lesion, but the related neurophysiological changes are still not clear. Here, we investigated the ability of ADS and random stimulation (RS) to alter firing patterns of distant cortical locations. We recorded 591 neuronal units from 23 Long-Evan healthy anesthetized rats. Stimulation was delivered to either forelimb or barrel field somatosensory cortex, using either RS or ADS triggered from spikes recorded in the rostral forelimb area (RFA). Both RS and ADS stimulation protocols rapidly altered spike firing within RFA compared with no stimulation. We observed increase in firing rates and change of spike patterns. ADS was more effective than RS in increasing evoked spikes during the stimulation periods, by producing a reliable, progressive increase in stimulus-related activity over time and an increased coupling of the trigger channel with the network. These results are critical for understanding the efficacy of closed-loop electrical microstimulation protocols in altering activity patterns in interconnected brain networks, thus modulating cortical state and functional connectivity.
Identifiants
pubmed: 31832642
pii: 5673779
doi: 10.1093/cercor/bhz281
pmc: PMC7197073
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2879-2896Subventions
Organisme : NINDS NIH HHS
ID : R01 NS030853
Pays : United States
Organisme : NICHD NIH HHS
ID : R03 HD094608
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD057850
Pays : United States
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permission@oup.com.
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