Uptake pattern of [68Ga]Ga-DOTA-NOC in tissues: implications for inflammatory diseases.

Heterocyclic Compounds, 1-Ring Humans Neuroendocrine Tumors / metabolism Organometallic Compounds Positron-Emission Tomography / methods Retrospective Studies

Journal

The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...
ISSN: 1827-1936
Titre abrégé: Q J Nucl Med Mol Imaging
Pays: Italy
ID NLM: 101213861

Informations de publication

Date de publication:
Jun 2022
Historique:
pubmed: 14 12 2019
medline: 20 5 2022
entrez: 14 12 2019
Statut: ppublish

Résumé

[68Ga]Ga-DOTA-NOC binds to somatostatin receptor (SSTR) subtypes 2 and 5, also expressed on lymphocytes and macrophages, but no information is available about uptake in tissues that might be affected by a chronic inflammatory process. Our aim was to obtain normal reference values for: [68Ga]Ga-DOTA-NOC uptake in tissues prone to chronic inflammation. Retrospective study in 81 patients who performed the scan for a suspicion of neuroendocrine tumor (NET). We analyzed major joints, salivary glands, thyroid, aortic wall from images acquired after injection of 173.9±1 Mbq of: [68Ga]Ga-DOTA-NOC. We calculated the SUV<inf>max</inf> and SUV<inf>target</inf>/SUV<inf>gluteus</inf> ratio or SUV<inf>target</inf>/SUV<inf>aorta</inf> ratio. Data are reported as mean±2 or ±3 standard deviations (SD). SUV<inf>max</inf> values appeared more reliable than other ratios. In thyroid we found a mean SUV<inf>max</inf> of 1.36±0.45, with no values >3SD; in parotid glands 0.98±0.40, with 2 values >3SD; in submandibular glands 0.99±0.37, with 2 values >3SD; in aortic arch 1.71±0.50, with 1 value >3SD; in thoracic aorta 2.03±0.52, with 1 value >3SD; in abdominal aorta 2.19±0.49, with no value >3SD; in shoulders 0.92±0.31 and in hips 0.87±0.34, with 2 and 4 values >3SD, respectively. These 12 values with SUV<inf>max</inf> >3SD, belong to 5 patients, 3 of which had signs of xerostomia and/or arthritis. A statistically significant correlation was observed between SUV<inf>max</inf> and age in all examined tissues but in the aorta. Tissues in which lymphocytic infiltration may occur show that SUV<inf>max</inf> is tissue-dependent. Within tissue variability, an SUV<inf>max</inf> greater than the mean +3SD is rarely found amongst patients without a symptomatic chronic inflammatory process but, when found, may highlight a chronic inflammatory condition.

Sections du résumé

BACKGROUND BACKGROUND
[68Ga]Ga-DOTA-NOC binds to somatostatin receptor (SSTR) subtypes 2 and 5, also expressed on lymphocytes and macrophages, but no information is available about uptake in tissues that might be affected by a chronic inflammatory process. Our aim was to obtain normal reference values for: [68Ga]Ga-DOTA-NOC uptake in tissues prone to chronic inflammation.
METHODS METHODS
Retrospective study in 81 patients who performed the scan for a suspicion of neuroendocrine tumor (NET). We analyzed major joints, salivary glands, thyroid, aortic wall from images acquired after injection of 173.9±1 Mbq of: [68Ga]Ga-DOTA-NOC. We calculated the SUV<inf>max</inf> and SUV<inf>target</inf>/SUV<inf>gluteus</inf> ratio or SUV<inf>target</inf>/SUV<inf>aorta</inf> ratio. Data are reported as mean±2 or ±3 standard deviations (SD).
RESULTS RESULTS
SUV<inf>max</inf> values appeared more reliable than other ratios. In thyroid we found a mean SUV<inf>max</inf> of 1.36±0.45, with no values >3SD; in parotid glands 0.98±0.40, with 2 values >3SD; in submandibular glands 0.99±0.37, with 2 values >3SD; in aortic arch 1.71±0.50, with 1 value >3SD; in thoracic aorta 2.03±0.52, with 1 value >3SD; in abdominal aorta 2.19±0.49, with no value >3SD; in shoulders 0.92±0.31 and in hips 0.87±0.34, with 2 and 4 values >3SD, respectively. These 12 values with SUV<inf>max</inf> >3SD, belong to 5 patients, 3 of which had signs of xerostomia and/or arthritis. A statistically significant correlation was observed between SUV<inf>max</inf> and age in all examined tissues but in the aorta.
CONCLUSIONS CONCLUSIONS
Tissues in which lymphocytic infiltration may occur show that SUV<inf>max</inf> is tissue-dependent. Within tissue variability, an SUV<inf>max</inf> greater than the mean +3SD is rarely found amongst patients without a symptomatic chronic inflammatory process but, when found, may highlight a chronic inflammatory condition.

Identifiants

DOI: 10.23736/S1824-4785.19.03178-9 PMID: 31833738
pubmed: 31833738
pii: S1824-4785.19.03178-9
doi: 10.23736/S1824-4785.19.03178-9
doi:

Substances chimiques

Heterocyclic Compounds, 1-Ring 0
Organometallic Compounds 0
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid 1HTE449DGZ

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

156-161

Auteurs

Luz K Anzola (LK)

Unit of Nuclear Medicine, Clinica Colsanitas, Bogotà, Colombia - lkanzola@gmail.com.
Unit of Nuclear Medicine, Department of Medical-Surgical Sciences and of Translational Medicine, Sapienza University, Rome, Italy - lkanzola@gmail.com.
Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands - lkanzola@gmail.com.

Chiara Lauri (C)

Unit of Nuclear Medicine, Department of Medical-Surgical Sciences and of Translational Medicine, Sapienza University, Rome, Italy.

Carlos E Granados (CE)

Medicina Nuclear, Hospital San Ignacio, Bogotá, Colombia.

Bruno Laganà (B)

Unit of Rheumatology, Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.

Alberto Signore (A)

Unit of Nuclear Medicine, Department of Medical-Surgical Sciences and of Translational Medicine, Sapienza University, Rome, Italy.
Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Uptake pattern of [68Ga]Ga-DOTA-NOC in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Uptake pattern of [68Ga]Ga-DOTA-NOC in...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Uptake pattern of [68Ga]Ga-DOTA-NOC in...
questionsmedicales.fr › Composés chimiques organiques › Composés organométalliques › Uptake pattern of [68Ga]Ga-DOTA-NOC in...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Uptake pattern of [68Ga]Ga-DOTA-NOC in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Uptake pattern of [68Ga]Ga-DOTA-NOC in...