Duration and Density of Fecal Rotavirus Shedding in Vaccinated Malawian Children With Rotavirus Gastroenteritis.
rotavirus
shedding
transmission
vaccine effectiveness
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
13 11 2020
13 11 2020
Historique:
received:
01
08
2019
accepted:
04
12
2019
pubmed:
14
12
2019
medline:
2
4
2021
entrez:
14
12
2019
Statut:
ppublish
Résumé
Quantifying rotavirus shedding among vaccinated individuals will aid understanding of vaccine indirect effects. Serial stool samples were collected from 196 children who presented with rotavirus gastroenteritis to health facilities in Blantyre, Malawi, and were tested for rotavirus using a VP6 semi-quantitative, real-time polymerase chain reaction. The median duration of fecal shedding was 28 days (95% CI, 19-28). The median copy numbers for peak shedding were 1.99 × 107 (interquartile range, 3.39 × 106 to 6.37 × 107). The fecal viral load was positively associated with disease severity and negatively associated with serum anti-rotavirus immunoglobin A. High and persistent rotavirus shedding among vaccinated children with breakthrough disease may contribute to ongoing transmission in this setting.
Identifiants
pubmed: 31834930
pii: 5676855
doi: 10.1093/infdis/jiz612
pmc: PMC7661767
doi:
Substances chimiques
NSP3 protein, Rotavirus
0
Rotavirus Vaccines
0
Viral Nonstructural Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2035-2040Subventions
Organisme : Wellcome Trust
ID : 201945/Z/16/Z
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI112970
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI125842
Pays : United States
Organisme : Wellcome Trust
ID : 102466/Z/13/A
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102464/Z/13/A
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 091909/Z/10/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 101113/Z/13/Z
Pays : United Kingdom
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.
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