IL-15 and CD155 expression regulate LAT expression in murine DNAM1
Adaptor Proteins, Signal Transducing
/ genetics
Animals
Antigens, Differentiation, T-Lymphocyte
/ metabolism
Calcium Signaling
Cells, Cultured
Cytotoxicity, Immunologic
DNA-Binding Proteins
/ genetics
Interleukin-15
/ genetics
Killer Cells, Natural
/ immunology
Large Neutral Amino Acid-Transporter 1
/ genetics
Lymphocyte Activation
Lymphocyte Depletion
Mice
Mice, Inbred C57BL
Mice, Knockout
Nuclear Proteins
/ genetics
Receptors, Virus
/ genetics
Transcription Factors
/ genetics
Transcriptional Activation
CD155
DNAM1
IL-15
LAT
NK cells
Journal
European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
02
05
2019
revised:
14
10
2019
accepted:
11
12
2019
pubmed:
14
12
2019
medline:
11
8
2020
entrez:
14
12
2019
Statut:
ppublish
Résumé
NK cells are innate immune cells characterized by their ability to spontaneously lyse tumor and virally infected cells. We have recently demonstrated that IL-15-sufficient DC regulate NK cell effector functions in mice. Here, we established that among ITAM-proximal signaling molecules, the expression levels of the scaffold molecule Linker for Activation of T cells (LAT) and its transcription factor ELF-1 were reduced 4 days after in vivo depletion of DC. Addition of IL-15, a cytokine presented by DC to NK cells, regulates LAT expression in NK cells with a significant effect on the DNAM1
Identifiants
pubmed: 31834938
doi: 10.1002/eji.201948233
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Antigens, Differentiation, T-Lymphocyte
0
CD226 antigen
0
DNA-Binding Proteins
0
Elf1 protein, mouse
0
Interleukin-15
0
LAT2 protein, mouse
0
Large Neutral Amino Acid-Transporter 1
0
Nuclear Proteins
0
Receptors, Virus
0
Transcription Factors
0
poliovirus receptor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
494-504Subventions
Organisme : Swedish Research Council
ID : 2011-03152
Pays : International
Organisme : Swedish Cancer Society
ID : 2015/727
Pays : International
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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