Aldh2 Attenuates Stem Cell Factor/Kit-Dependent Signaling and Activation in Mast Cells.

Aldehyde Dehydrogenase, Mitochondrial / genetics Animals Cell Line Cell Proliferation Gene Knockout Techniques Mast Cells / cytology Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 6 Proto-Oncogene Proteins c-kit / metabolism Reactive Oxygen Species / metabolism Signal Transduction Stem Cell Factor / metabolism
Aldh2 deficiency Kit Shp-1 mast cell activation mast cells proliferation

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
10 Dec 2019
Historique:
received: 13 11 2019
revised: 04 12 2019
accepted: 05 12 2019
entrez: 15 12 2019
pubmed: 15 12 2019
medline: 28 4 2020
Statut: epublish

Résumé

Mitochondrial aldehyde dehydrogenase (ALDH2) metabolizes endogenous and exogenous aldehydes and protects cells against oxidative injury. Inactivating genetic polymorphisms in humans are common and associate with alcohol flush reactions. However, whether mast cell Aldh2 activity impacts normal mast cell responses is unknown. Using bone marrow-derived mast cells from

Identifiants

DOI: 10.3390/ijms20246216 PMID: 31835486 PMC: PMC6940998
pubmed: 31835486
pii: ijms20246216
doi: 10.3390/ijms20246216
pmc: PMC6940998
pii:
doi:

Substances chimiques

Kit protein, mouse 0
Reactive Oxygen Species 0
Stem Cell Factor 0
ALDH2 protein, mouse EC 1.2.1.3
Aldehyde Dehydrogenase, Mitochondrial EC 1.2.1.3
Proto-Oncogene Proteins c-kit EC 2.7.10.1
Protein Tyrosine Phosphatase, Non-Receptor Type 6 EC 3.1.3.48
Ptpn6 protein, mouse EC 3.1.3.48

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Division of Intramural Research, National Institute of Allergy and Infectious Diseases
ID : AI001206

Références

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Auteurs

Do-Kyun Kim (DK)

Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

Young-Eun Cho (YE)

Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Bethesda, MD 20892, USA.

Byoung-Joon Song (BJ)

Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Bethesda, MD 20892, USA.
ORCID: 0000-0002-3954-3497

Toshihiro Kawamoto (T)

Occupational Health Research and Development Center, Japan Industrial Safety and Health Association, Tokyo 108-0014, Japan.

Dean D Metcalfe (DD)

Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
ORCID: 0000-0002-7781-8260

Ana Olivera (A)

Mast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Aldehyde dehydrogenase, mitochondrial › Aldh2 Attenuates Stem Cell...
questionsmedicales.fr › Eucaryotes › Animaux › Aldh2 Attenuates Stem Cell...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Aldh2 Attenuates Stem Cell...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Aldh2 Attenuates Stem Cell...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-out de gènes › Aldh2 Attenuates Stem Cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Mastocytes › Aldh2 Attenuates Stem Cell...
questionsmedicales.fr › Métabolisme › Phosphorylation › Aldh2 Attenuates Stem Cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › SH2 Domain-Containing Protein Tyrosine Phosphatases › Protein Tyrosine Phosphatase, Non-Receptor Type 6 › Aldh2 Attenuates Stem Cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-kit › Aldh2 Attenuates Stem Cell...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Aldh2 Attenuates Stem Cell...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Aldh2 Attenuates Stem Cell...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de croissance hématopoïétique › Facteur de croissance des cellules souches › Aldh2 Attenuates Stem Cell...