The antioxidant and immunomodulatory compound 3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole attenuates depression-like behavior and cognitive impairment developed in a mouse model of breast tumor.
Animals
Antioxidants
/ pharmacology
Breast Neoplasms
/ complications
Cognitive Dysfunction
/ drug therapy
Depression
/ drug therapy
Disease Models, Animal
Female
Humans
Indoles
/ pharmacology
Mice
Mice, Inbred BALB C
Molecular Docking Simulation
Oxidative Stress
/ drug effects
Quality of Life
Selenium Compounds
Antioxidant
Cognition
Depression
Immunomodulatory
Organoselenium
Tumor-bearing mice
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
25
09
2019
revised:
20
11
2019
accepted:
09
12
2019
pubmed:
15
12
2019
medline:
10
3
2021
entrez:
15
12
2019
Statut:
ppublish
Résumé
Psychiatric alterations are often found in patients with breast cancer even before the initiation of adjuvant therapy, resulting in a poor quality of life. It has become accepted that neuroinflammation and oxidative stress are involved in the pathophysiology of depression and cognitive impairment. Herein, we tested the hypothesis that treatment with the antioxidant and immunomodulatory selenium-containing compound 3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole (CMI)could attenuate behavioral and neurochemical alterations in a mammary (4T1) tumor model. Female BALB/c mice were subcutaneously inoculated with 4T1 cancer cells (1 × 10
Identifiants
pubmed: 31837417
pii: S0889-1591(19)31229-2
doi: 10.1016/j.bbi.2019.12.005
pii:
doi:
Substances chimiques
3-(4-chlorophenylselanyl)-1-methyl-1H-indole
0
Antioxidants
0
Indoles
0
Selenium Compounds
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
229-241Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.