Application of physiologically based kinetic (PBK) modelling in the next generation risk assessment of dermally applied consumer products.
Journal
Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Titre abrégé: Toxicol In Vitro
Pays: England
ID NLM: 8712158
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
06
11
2019
revised:
04
12
2019
accepted:
09
12
2019
pubmed:
15
12
2019
medline:
29
9
2020
entrez:
15
12
2019
Statut:
ppublish
Résumé
Next Generation Risk Assessment (NGRA) is a procedure that integrates new approach methodologies (NAMs) to assure safety of a product without generating data from animal testing. One of the major challenges in the application of NGRA to consumer products is how to extrapolate from the in vitro points of departure (PoDs) to the human exposure level associated with product use. To bridge the gap, physiologically based kinetic (PBK) modelling is routinely used to predict systemic exposure (C
Identifiants
pubmed: 31837441
pii: S0887-2333(19)30834-3
doi: 10.1016/j.tiv.2019.104746
pii:
doi:
Substances chimiques
Cosmetics
0
Coumarins
0
Detergents
0
Isothiocyanates
0
Sulfoxides
0
Caffeine
3G6A5W338E
coumarin
A4VZ22K1WT
sulforaphane
GA49J4310U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104746Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.