Effect of Calcium on the Hydrolysis Activity of Human Butyrylcholinesterase.
drug metabolizing enzymes(s)
enzyme kinetics
enzyme(s)
hydrolysis
metabolism
phase I enzymes(s)
Journal
Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
30
08
2019
revised:
07
11
2019
accepted:
05
12
2019
pubmed:
16
12
2019
medline:
22
6
2021
entrez:
16
12
2019
Statut:
ppublish
Résumé
The aim of this experiment was to study the effects of calcium ion on the hydrolysis of cationic and anionic substrate by human butyrylcholinesterase (HuBChE). The hydrolysis of aspirin, an anionic substrate, by HuBChE was markedly increased in the presence of increasing concentrations of calcium ion (∼20 mM), as shown by the increasing k
Identifiants
pubmed: 31837977
pii: S0022-3549(19)30812-3
doi: 10.1016/j.xphs.2019.12.006
pii:
doi:
Substances chimiques
Butyrylcholinesterase
EC 3.1.1.8
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1417-1420Informations de copyright
Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.