Allostery in C-type lectins.

Allosteric Regulation Animals Binding Sites Humans Lectins, C-Type / chemistry Models, Molecular Protein Binding Protein Conformation Structure-Activity Relationship

Journal

Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784

Informations de publication

Date de publication:
06 2020
Historique:
received: 30 09 2019
revised: 30 10 2019
accepted: 04 11 2019
pubmed: 16 12 2019
medline: 23 7 2021
entrez: 16 12 2019
Statut: ppublish

Résumé

C-type lectins are the largest and most diverse family of mammalian carbohydrate-binding proteins. They share a common protein fold, which provides the unifying basis for calcium-mediated carbohydrate recognition. Their involvement in a multitude of biological functions is remarkable. Here, we review the variety of tasks these lectins are involved in alongside with the structural demands on the overall protein architecture. Subtle changes of the protein structure are implemented to cope with such diverse functional requirements. The presence of a high level of structural dynamics over a broad palette of time scales is paired with the presence of secondary binding sites and allosteric coordination of remote sites and renders this lectin fold a highly adaptable scaffold.

Identifiants

DOI: 10.1016/j.sbi.2019.11.003 PMID: 31838280
pubmed: 31838280
pii: S0959-440X(19)30123-X
doi: 10.1016/j.sbi.2019.11.003
pii:
doi:

Substances chimiques

Lectins, C-Type 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

31-38

Informations de copyright

Copyright © 2019. Published by Elsevier Ltd.

Auteurs

Bettina G Keller (BG)

Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany.

Christoph Rademacher (C)

Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, 14195 Berlin, Germany; Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, 14424 Potsdam, Germany. Electronic address: christoph.rademacher@mpikg.mpg.de.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › Allostery in C-type lectins.
questionsmedicales.fr › Eucaryotes › Animaux › Allostery in C-type lectins.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Allostery in C-type lectins.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Allostery in C-type lectins.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Lectines de type C › Allostery in C-type lectins.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Allostery in C-type lectins.
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Allostery in C-type lectins.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Allostery in C-type lectins.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Allostery in C-type lectins.