Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue.
Adult
Aged
Body Composition
Female
Humans
Intra-Abdominal Fat
/ diagnostic imaging
Male
Middle Aged
Muscles
/ diagnostic imaging
Odds Ratio
Pancreatitis
/ diagnostic imaging
ROC Curve
Radiographic Image Enhancement
Severity of Illness Index
Subcutaneous Fat
/ diagnostic imaging
Tomography, X-Ray Computed
/ methods
Acute pancreatitis
mean muscle attenuation
muscle mass
severity
visceral adipose tissue
Journal
United European gastroenterology journal
ISSN: 2050-6414
Titre abrégé: United European Gastroenterol J
Pays: England
ID NLM: 101606807
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
01
05
2019
accepted:
18
09
2019
entrez:
17
12
2019
pubmed:
17
12
2019
medline:
1
7
2020
Statut:
ppublish
Résumé
Acute pancreatitis (AP) is a frequent disorder with considerable morbidity and mortality. Obesity has previously been reported to influence disease severity. The aim of this study was to investigate the association of adipose and muscle parameters with the severity grade of AP. In total 454 patients were recruited. The first contrast-enhanced computed tomography of each patient was reviewed for adipose and muscle tissue parameters at L3 level. Associations with disease severity were analysed through logistic regression analysis. The predictive capacity of the parameters was investigated using receiver operating characteristic (ROC) curves. No distinct variation was found between the AP severity groups in either adipose tissue parameters (visceral adipose tissue and subcutaneous adipose tissue) or visceral muscle ratio. However, muscle mass and mean muscle attenuation differed significantly with Our results demonstrate that a low muscle attenuation level is associated with an increased risk of severe AP. Future prospective studies will help identify the underlying mechanisms and characterise the influence of body composition parameters on AP.
Sections du résumé
Background
Acute pancreatitis (AP) is a frequent disorder with considerable morbidity and mortality. Obesity has previously been reported to influence disease severity.
Objective
The aim of this study was to investigate the association of adipose and muscle parameters with the severity grade of AP.
Methods
In total 454 patients were recruited. The first contrast-enhanced computed tomography of each patient was reviewed for adipose and muscle tissue parameters at L3 level. Associations with disease severity were analysed through logistic regression analysis. The predictive capacity of the parameters was investigated using receiver operating characteristic (ROC) curves.
Results
No distinct variation was found between the AP severity groups in either adipose tissue parameters (visceral adipose tissue and subcutaneous adipose tissue) or visceral muscle ratio. However, muscle mass and mean muscle attenuation differed significantly with
Conclusions
Our results demonstrate that a low muscle attenuation level is associated with an increased risk of severe AP. Future prospective studies will help identify the underlying mechanisms and characterise the influence of body composition parameters on AP.
Identifiants
pubmed: 31839956
doi: 10.1177/2050640619882520
pii: 10.1177_2050640619882520
pmc: PMC6893994
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1312-1320Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK092460
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© Author(s) 2019.
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