The excitable signal transduction networks: movers and shapers of eukaryotic cell migration.
Journal
The International journal of developmental biology
ISSN: 1696-3547
Titre abrégé: Int J Dev Biol
Pays: Spain
ID NLM: 8917470
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
17
12
2019
pubmed:
17
12
2019
medline:
9
7
2020
Statut:
ppublish
Résumé
In response to a variety of external cues, eukaryotic cells display varied migratory modes to perform their physiological functions during development and in the adult. Aberrations in cell migration result in embryonic defects and cancer metastasis. The molecular components involved in cell migration are remarkably conserved between the social amoeba Dictyostelium and mammalian cells. This makes the amoeba an excellent model system for studies of eukaryotic cell migration. These migration-associated components can be grouped into three networks: input, signal transduction and cytoskeletal. In migrating cells, signal transduction events such as Ras or PI3K activity occur at the protrusion tips, referred to as 'front', whereas events such as dissociation of PTEN from these regions are referred to as 'back'. Asymmetric distribution of such front and back events is crucial for establishing polarity and guiding cell migration. The triggering of these signaling events displays properties of biochemical excitability including all-or-nothing responsiveness to suprathreshold stimuli, refractoriness, and wave propagation. These signal transduction waves originate from a point and propagate towards the edge of the cell, thereby driving cytoskeletal activity and cellular protrusions. Any change in the threshold for network activation alters the range of the propagating waves and the size of cellular protrusions which gives rise to various migratory modes in cells. Thus, this review highlights excitable signal transduction networks as key players for coordinating cytoskeletal activities to drive cell migration in all eukaryotes.
Identifiants
pubmed: 31840779
pii: 190265pd
doi: 10.1387/ijdb.190265pd
pmc: PMC6956983
mid: NIHMS1066552
doi:
Substances chimiques
Actins
0
ras Proteins
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
407-416Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM118177
Pays : United States
Organisme : NIH HHS
ID : S10 OD016374
Pays : United States
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