Optimized Xenograft Protocol for Chronic Lymphocytic Leukemia Results in High Engraftment Efficiency for All CLL Subgroups.
CLL
microenvironment
xenograft
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Dec 2019
12 Dec 2019
Historique:
received:
21
11
2019
revised:
03
12
2019
accepted:
06
12
2019
entrez:
18
12
2019
pubmed:
18
12
2019
medline:
1
5
2020
Statut:
epublish
Résumé
Preclinical drug development for human chronic lymphocytic leukemia (CLL) requires robust xenograft models recapitulating the entire spectrum of the disease, including all prognostic subgroups. Current CLL xenograft models are hampered by inefficient engraftment of good prognostic CLLs, overgrowth with co-transplanted T cells, and the need for allogeneic humanization or irradiation. Therefore, we aimed to establish an effective and reproducible xenograft protocol which allows engraftment of all CLL subtypes without the need of humanization or irradiation. Unmanipulated NOD.Cg-
Identifiants
pubmed: 31842407
pii: ijms20246277
doi: 10.3390/ijms20246277
pmc: PMC6940872
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Krebshilfe
ID : 111025
Organisme : Deutsche Krebshilfe
ID : 70112614
Organisme : Deutsche Forschungsgemeinschaft
ID : DI 1664/1-1
Organisme : Deutsche Forschungsgemeinschaft
ID : DI 1664/2-2
Organisme : Deutsche Forschungsgemeinschaft
ID : DI 1664/3-1
Organisme : José Carreras Leukämie-Stiftung
ID : DJCLS F15/3
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