MKC-Quatsomes: a stable nanovesicle platform for bio-imaging and drug-delivery applications.
Bio-imaging
Drug-delivery system
Lipid-based vesicles
Nanocarrier
Nanomedicine
Quatsomes
Journal
Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
07
06
2019
revised:
05
11
2019
accepted:
22
11
2019
pubmed:
18
12
2019
medline:
24
11
2020
entrez:
18
12
2019
Statut:
ppublish
Résumé
Quatsomes are outstanding new lipid-based nanovesicles that are highly homogeneous and stable in different media for years, but the composition must be carefully chosen to avoid any potentially toxic side effects in in vivo applications. To this end, we have developed and studied a novel type of Quatsomes composed of cholesterol and myristalkonium chloride (MKC), the latter being extensively used as antimicrobial preservative in many ophthalmic and parenteral formulations on the EU and USA market. We have synthesized these novel MKC-Quatsomes in different media that are suitable for parenteral administration, and confirmed their stability in these media for 18 months, as well as the stability in human serum for 24 hours. Biodistribution assays were performed after intravenous injection of fluorescently labeled MKC-Quatsomes in live mice bearing xenografted colorectal tumors, showing nanovesicle accumulation in tumors, liver, spleen, and kidneys. No histological alteration or toxicity was observed in any of these organs.
Identifiants
pubmed: 31843659
pii: S1549-9634(19)30220-5
doi: 10.1016/j.nano.2019.102136
pii:
doi:
Substances chimiques
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102136Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.