Evidence of Tissue Repair in Human Donor Pancreas After Prolonged Duration of Stay in Intensive Care.
Adolescent
Adult
Antigens, CD
/ metabolism
Antigens, Differentiation, Myelomonocytic
/ metabolism
Cell Proliferation
/ physiology
Female
Humans
Intensive Care Units
Ki-67 Antigen
/ metabolism
Lectins, C-Type
/ metabolism
Length of Stay
Macrophages
/ metabolism
Male
Mannose Receptor
Mannose-Binding Lectins
/ metabolism
Middle Aged
Neovascularization, Physiologic
/ physiology
Pancreas
/ metabolism
Receptors, Cell Surface
/ metabolism
Regeneration
/ physiology
Tissue Donors
Young Adult
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
28
05
2019
accepted:
10
12
2019
pubmed:
18
12
2019
medline:
4
8
2020
entrez:
18
12
2019
Statut:
ppublish
Résumé
M2 macrophages play an important role in tissue repair and regeneration. They have also been found to modulate β-cell replication in mouse models of pancreatic injury and disease. We previously reported that β-cell replication is strongly increased in a subgroup of human organ donors characterized by prolonged duration of stay in an intensive care unit (ICU) and increased number of leukocytes in the pancreatic tissue. In the present study we investigated the relationship between duration of stay in the ICU, M2 macrophages, vascularization, and pancreatic cell replication. Pancreatic organs from 50 donors without diabetes with different durations of stay in the ICU were analyzed by immunostaining and digital image analysis. The number of CD68
Identifiants
pubmed: 31843955
pii: db19-0529
doi: 10.2337/db19-0529
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, Myelomonocytic
0
CD68 antigen, human
0
Ki-67 Antigen
0
Lectins, C-Type
0
MKI67 protein, human
0
Mannose Receptor
0
Mannose-Binding Lectins
0
Receptors, Cell Surface
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
401-412Informations de copyright
© 2019 by the American Diabetes Association.