Severe mononeuritis multiplex in a patient with eosinophilic granulomatosis with polyangiitis.
eosinophilic granulomatosis with polyangiitis
granulomatosis process
mononeuritis multiplex
vasculitis
Journal
Reumatologia
ISSN: 0034-6233
Titre abrégé: Reumatologia
Pays: Poland
ID NLM: 20130190R
Informations de publication
Date de publication:
2019
2019
Historique:
received:
19
08
2019
accepted:
17
10
2019
entrez:
18
12
2019
pubmed:
18
12
2019
medline:
18
12
2019
Statut:
ppublish
Résumé
Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis characterised by bronchial asthma, hypereosinophilia, and systemic vasculitis. History of asthma with blood eosinophilia and multiorgan involvement are the important clues to suspect EGPA. In the original paper by Churg and Strauss cardiac, gastrointestinal tract, renal, and neurological involvement were noted more frequently. The pattern of neurological involvement may be mononeuritis multiplex, and symmetrical and asymmetrical polyneuropathy. Mononeuritis multiplex was present in 78.1% while cranial nerves were involved in only 4.1% of cases. Glucocorticosteroids and immunosuppressants, especially cyclophosphamide, have considerably improved the prognosis and overall survival rates in patients with systemic vasculitis, including eosinophilic granulomatosis with polyangiitis. The authors present a clinical case of eosinophilic granulomatosis with polyangiitis with severe mononeuritis multiplex. The case reflects the successful application of a cyclophosphamide regime as a remission inducer.
Identifiants
pubmed: 31844342
doi: 10.5114/reum.2019.89522
pii: 89522
pmc: PMC6911252
doi:
Types de publication
Case Reports
Langues
eng
Pagination
288-291Informations de copyright
Copyright: © 2019 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Can J Surg. 2008 Dec;51(6):E129-30
pubmed: 19057725
Radiographics. 2007 May-Jun;27(3):617-37; discussion 637-9
pubmed: 17495282
Nat Rev Rheumatol. 2017 Sep;13(9):518-519
pubmed: 28769112
Arthritis Rheum. 1990 Aug;33(8):1094-100
pubmed: 2202307
Case Rep Gastroenterol. 2014 Oct 28;8(3):329-36
pubmed: 25473392
JAMA. 2007 Aug 8;298(6):655-69
pubmed: 17684188
Am J Pathol. 1951 Mar-Apr;27(2):277-301
pubmed: 14819261
Eur J Intern Med. 2015 Sep;26(7):545-53
pubmed: 25971154
Arthritis Rheum. 2007 May 15;57(4):686-93
pubmed: 17471546
BMJ Case Rep. 2017 May 27;2017:null
pubmed: 28551593
Mod Pathol. 2001 Dec;14(12):1284-93
pubmed: 11743052
Arthritis Rheum. 2005 Sep;52(9):2926-35
pubmed: 16142760
J Autoimmun. 2014 Feb-Mar;48-49:99-103
pubmed: 24530234
Medicine (Baltimore). 1999 Jan;78(1):26-37
pubmed: 9990352
Ann Rheum Dis. 2016 Sep;75(9):1583-94
pubmed: 27338776
Clin Neuropathol. 2011 Jan-Feb;30(1):11-7
pubmed: 21176712
Arthritis Rheum. 2013 Jan;65(1):1-11
pubmed: 23045170
N Engl J Med. 2013 Aug 1;369(5):417-27
pubmed: 23902481