Maternal and Neonatal Outcomes in Patients of Gestational Diabetes Mellitus on Metformin Therapy.

Gestational diabetes mellitus Maternal and neonatal outcomes Metformin

Journal

Journal of obstetrics and gynaecology of India

ISSN: 0971-9202

Titre abrégé: J Obstet Gynaecol India

Pays: India

ID NLM: 0374763

Informations de publication

Date de publication:
Dec 2019

Historique:

received: 13 09 2018

accepted: 04 03 2019

entrez: 18 12 2019

pubmed: 18 12 2019

medline: 18 12 2019

Statut: ppublish

Résumé

Present study carried out in a tertiary referral hospital in North India attempts to determine the maternal and neonatal outcomes of metformin therapy in patients of gestational diabetes mellitus. To evaluate maternal and neonatal outcomes in patients of GDM on metformin therapy and to study its adverse effects. In this prospective observational study, all women diagnosed with GDM not controlled by medical nutrition therapy were started on metformin therapy and the maternal and neonatal outcomes were studied. A total of 104 patients of GDM, not controlled on MNT and requiring pharmacotherapy, were enrolled for the study. An important clinical data from the study were that in 63.5% of patients there was no family history of diabetes mellitus. Average weight gain during pregnancy ranged from 6 to 10 kg. Glycemic control was achieved in 96.2% of patients with varying doses of metformin therapy, and it reached statistical significance. Duration of metformin therapy ranged from a minimum of 2 months to a maximum of 6 months. No serious side effects were noted except for hypoglycemia in one patient. Patient acceptability toward metformin intake was good. Mean birth weight of newborns was 2972 ± 280 g, and no case of fetal macrosomia was seen. Neonatal hypoglycemia was seen in 3.8% of the babies and 6.7% required NICU admission. No case of congenital malformation was reported. Metformin is a clinically effective, inexpensive and safe drug for treating gestational diabetes mellitus.

Sections du résumé

BACKGROUND BACKGROUND

Present study carried out in a tertiary referral hospital in North India attempts to determine the maternal and neonatal outcomes of metformin therapy in patients of gestational diabetes mellitus.

OBJECTIVES OBJECTIVE

To evaluate maternal and neonatal outcomes in patients of GDM on metformin therapy and to study its adverse effects.

METHOD METHODS

In this prospective observational study, all women diagnosed with GDM not controlled by medical nutrition therapy were started on metformin therapy and the maternal and neonatal outcomes were studied.

RESULTS RESULTS

A total of 104 patients of GDM, not controlled on MNT and requiring pharmacotherapy, were enrolled for the study. An important clinical data from the study were that in 63.5% of patients there was no family history of diabetes mellitus. Average weight gain during pregnancy ranged from 6 to 10 kg. Glycemic control was achieved in 96.2% of patients with varying doses of metformin therapy, and it reached statistical significance. Duration of metformin therapy ranged from a minimum of 2 months to a maximum of 6 months. No serious side effects were noted except for hypoglycemia in one patient. Patient acceptability toward metformin intake was good. Mean birth weight of newborns was 2972 ± 280 g, and no case of fetal macrosomia was seen. Neonatal hypoglycemia was seen in 3.8% of the babies and 6.7% required NICU admission. No case of congenital malformation was reported.

CONCLUSIONS CONCLUSIONS

Metformin is a clinically effective, inexpensive and safe drug for treating gestational diabetes mellitus.

Identifiants

DOI: 10.1007/s13224-019-01216-4 PMID: 31844362 PMC: PMC6889106

pubmed: 31844362

doi: 10.1007/s13224-019-01216-4

pii: 1216

pmc: PMC6889106

doi:

Types de publication

Journal Article

Langues

eng

Pagination

490-494

Informations de copyright

Déclaration de conflit d'intérêts

Conflicts of interestThere is no conflict of interest.

Références

Diabetes Res Clin Pract. 2015 Feb;107(2):290-9

pubmed: 25467617

Am J Obstet Gynecol. 2013 Jul;209(1):34.e1-7

pubmed: 23524173

Diabetes Res Clin Pract. 2015 Sep;109(3):521-32

pubmed: 26117686

Diabetes Res Clin Pract. 2012 Dec;98(3):422-9

pubmed: 23068960

N Engl J Med. 2008 May 8;358(19):2003-15

pubmed: 18463376

Aust N Z J Obstet Gynaecol. 2015 Feb;55(1):47-52

pubmed: 25688819

Semin Perinatol. 2014 Dec;38(8):508-15

pubmed: 25315294