Oxidative Stress and Anti-Oxidant Markers in Premature Infants with Respiratory Distress Syndrome.
Antioxidant enzymes
Newborn
Oxidative stress
Respiratory distress disorder
Journal
Open access Macedonian journal of medical sciences
ISSN: 1857-9655
Titre abrégé: Open Access Maced J Med Sci
Pays: North Macedonia
ID NLM: 101662294
Informations de publication
Date de publication:
15 Sep 2019
15 Sep 2019
Historique:
received:
01
06
2019
revised:
24
07
2019
accepted:
25
07
2019
entrez:
18
12
2019
pubmed:
18
12
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Neonatal respiratory distress syndrome (RDS) caused by decreased surfactant and structural lung immaturity. The imbalance between oxidative status and antioxidant defence system was suggested to be an important trigger for lung affection with RDS. The goal of the current research was to elucidate the significance of the oxidant/ antioxidant status in the pathogenesis of RDS in preterm infants. This controlled study included 31 preterm neonates with RDS and 36 healthy preterm neonates. Quantification level of oxidative stress biomarkers; malondialdehyde (MDA) & hydrogen peroxide (H status of oxidative stress markers (MDA & H The results obtained in this study indicate that the increased oxidative stress accompanied by reduced antioxidant defences may play a significant role in the pathogenesis of respiratory distress in preterm newborns.
Sections du résumé
BACKGROUND
BACKGROUND
Neonatal respiratory distress syndrome (RDS) caused by decreased surfactant and structural lung immaturity. The imbalance between oxidative status and antioxidant defence system was suggested to be an important trigger for lung affection with RDS.
AIM
OBJECTIVE
The goal of the current research was to elucidate the significance of the oxidant/ antioxidant status in the pathogenesis of RDS in preterm infants.
PATIENTS AND METHODS
METHODS
This controlled study included 31 preterm neonates with RDS and 36 healthy preterm neonates. Quantification level of oxidative stress biomarkers; malondialdehyde (MDA) & hydrogen peroxide (H
RESULTS
RESULTS
status of oxidative stress markers (MDA & H
CONCLUSION
CONCLUSIONS
The results obtained in this study indicate that the increased oxidative stress accompanied by reduced antioxidant defences may play a significant role in the pathogenesis of respiratory distress in preterm newborns.
Identifiants
pubmed: 31844449
doi: 10.3889/oamjms.2019.534
pii: OAMJMS-7-2858
pmc: PMC6901850
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2858-2863Informations de copyright
Copyright: © 2019 Enas R. Abdel Hamid, Walaa H. Ali, Ashraf Azmy, Hanaa H. Ahmed, Lobna S. Sherif, Maysa T. Saleh.
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