The cell-based approach in neurosurgery: ongoing trends and future perspectives.
Biotechnology
CAR T-Cell therapy
Cancer research
Cell- and tissue-based therapy
Clinical research
Evidence-based medicine
Genetic therapy
Glioblastoma
Immunology
Immunotherapy
Molecular biology
Neuroscience
Neurosurgery
Oncology
Regenerative medicine
Stem cells
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
26
08
2019
revised:
11
10
2019
accepted:
06
11
2019
entrez:
18
12
2019
pubmed:
18
12
2019
medline:
18
12
2019
Statut:
epublish
Résumé
Examination of the current trends and future perspectives of the cell-based therapies in neurosurgery. A PubMed/MEDLINE-based systematic review has been performed combining the main Medical Subject Headings (MeSH) regarding the cell- and tissue-based therapies with the "Brain", "Spinal Cord", "Spine" and "Skull" MeSH terms. Only articles in English published in the last 10 years and pertinent to neurosurgery have been selected. A total of 1,173 relevant articles have been chosen. Somatic cells and gene-modification technologies have undergone the greatest development. Immunotherapies and gene therapies have been tested for the cure of glioblastoma, stem cells mainly for brain and spinal cord traumatic injuries. Stem cells have also found a rationale in the treatment of the cranial and spinal bony defects, and of the intervertebral disc degeneration, as well.Most of the completed or ongoing trials concerning the cell-based therapies in neurosurgery are on phase 2. Future perspectives involve the need to overcome issues related to immunogenicity, oncogenicity and routes for administration. Refinement and improvement of vector design and delivery are required within the gene therapies. The last decade has been characterised by a progressive evolution of neurosurgery from a purely mechanical phase to a new biological one. This trend has followed the rapid and parallel development of translational medicine and nanotechnologies.The introduction of new technologies, the optimisation of the already existing ones, and the reduction of costs are among the main challenges of the foreseeable future.
Identifiants
pubmed: 31844735
doi: 10.1016/j.heliyon.2019.e02818
pii: S2405-8440(19)36478-3
pii: e02818
pmc: PMC6889232
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e02818Informations de copyright
© 2019 The Authors. Published by Elsevier Ltd.
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