The importance of caveolins and caveolae to dermatology: Lessons from the caves and beyond.
Bacterial Infections
/ metabolism
Caveolae
/ physiology
Caveolin 1
/ metabolism
Cell Movement
Cell Proliferation
Cellular Senescence
Fibrosis
/ metabolism
Hair
/ metabolism
Humans
Inflammation
/ metabolism
Lipid Metabolism
Psoriasis
/ metabolism
Signal Transduction
Skin
/ metabolism
Skin Neoplasms
/ metabolism
Skin Physiological Phenomena
Wound Healing
caveolae
caveolin-1
fibrosis
melanoma
psoriasis
squamous cell carcinoma
wound healing
Journal
Experimental dermatology
ISSN: 1600-0625
Titre abrégé: Exp Dermatol
Pays: Denmark
ID NLM: 9301549
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
07
10
2019
revised:
25
11
2019
accepted:
28
11
2019
pubmed:
18
12
2019
medline:
16
6
2021
entrez:
18
12
2019
Statut:
ppublish
Résumé
Caveolae are flask-shaped invaginations of the cell membrane rich in cholesterol and sphingomyelin, with caveolin proteins acting as their primary structural components that allow compartmentalization and orchestration of various signalling molecules. In this review, we discuss how pleiotropic functions of caveolin-1 (Cav1) and its intricate roles in numerous cellular functions including lipid trafficking, signalling, cell migration and proliferation, as well as cellular senescence, infection and inflammation, are integral for normal development and functioning of skin and its appendages. We then examine how disruption of the homeostatic levels of Cav1 can lead to development of various cutaneous pathophysiologies including skin cancers, cutaneous fibroses, psoriasis, alopecia, age-related changes in skin and aberrant wound healing and propose how levels of Cav1 may have theragnostic value in skin physiology/pathophysiology.
Identifiants
pubmed: 31845391
doi: 10.1111/exd.14068
pmc: PMC7028117
doi:
Substances chimiques
CAV1 protein, human
0
Caveolin 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
136-148Subventions
Organisme : Medline Wound Healing Foundation
Pays : International
Organisme : PhRMA Foundation
Pays : International
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2019 The Authors. Experimental Dermatology published by John Wiley & Sons Ltd.
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