[Autophagy and spermatozoa].
Autophagie et spermatozoïde.
Journal
Medecine sciences : M/S
ISSN: 1958-5381
Titre abrégé: Med Sci (Paris)
Pays: France
ID NLM: 8710980
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
entrez:
18
12
2019
pubmed:
18
12
2019
medline:
12
6
2020
Statut:
ppublish
Résumé
Spermiogenesis, the ultimate stage of spermatogenesis, is a process involving autophagy. At this stage, the acrosome is generated by vesicular fusion and most of the cytoplasm disappears. Autophagy, literally "eating oneself", allowing the elimination and replacement of proteins and nonfunctional organelles, ensures the recycling of cellular constituents and is a highly conserved cellular mechanism within eukaryotic cells. The machinery of autophagy is present in the spermatozoon, regulating the vitality and mobility of the cells. The environmental and behavioral impact on autophagy and the consequences on spermatogenesis are beginning to be studied. The purpose of this review is to synthesize current knowledge about autophagy in the mature male gamete. Autophagie et spermatozoïde. La spermiogenèse, étape ultime de la spermatogenèse, est un processus qui fait intervenir des acteurs qui participe à l’autophagie. C’est en effet lors de cette étape que se forme l’acrosome par fusion vésiculaire et que disparaît la majeure partie du cytoplasme du spermatozoïde. L’autophagie (littéralement « se manger soi-même »), en permettant l’élimination et le remplacement continuel des protéines et des organites non fonctionnels, assure le recyclage des constituants de la cellule. C’est un mécanisme cellulaire très conservé au sein des cellules eucaryotes. La machinerie de l’autophagie est également présente dans les spermatozoïdes. Elle régule la vitalité de ces cellules et leur mobilité. Les conséquences environnementales et comportementales sur l’autophagie et sur la spermatogenèse commencent à être étudiées. Le but de cette revue est de synthétiser les connaissances actuelles concernant les processus d’autophagie dans le gamète mâle mature.
Autres résumés
Type: Publisher
(fre)
Autophagie et spermatozoïde.
Identifiants
pubmed: 31845876
doi: 10.1051/medsci/2019172
pii: msc190146
doi:
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
852-858Informations de copyright
© 2019 médecine/sciences – Inserm.
Références
Ravel C, Berthaut I, Siffroi J-P. Infertilités masculines. Endocrinol-Nutr 2009 ; 10–032-E-10 : 1–18.
Ohsumi Y. Historical landmarks of autophagy research. Cell Res 2014 ; 24 : 9–23.
Mizushima N, Yoshimori T, Ohsumi Y. The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol 2011 ; 27 : 107–32.
Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol 2010 ; 221 : 3–12.
Galluzzi L, Baehrecke EH, Ballabio A, et al. Molecular definitions of autophagy and related processes. EMBO J 2017 ; 36 : 1811–36.
Gallardo Bolaños JM, Miró Morán Á, Balao da Silva CM, et al. Autophagy and apoptosis have a role in the survival or death of stallion spermatozoa during conservation in refrigeration. PLoS One 2012 ; 7 : e30688.
Bustamante-Marín X, Quiroga C, Lavandero S, et al. Apoptosis, necrosis and autophagy are influenced by metabolic energy sources in cultured rat spermatocytes. Apoptosis Int J Program Cell Death 2012 ; 17 : 539–50.
Herpin A, Englberger E, Zehner M, et al. Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria. FASEB J 2015 ; 29 : 4145–61.
Kraft C, Martens S. Mechanisms and regulation of autophagosome formation. Curr Opin Cell Biol 2012 ; 24 : 496–501.
Hailey DW, Rambold AS, Satpute-Krishnan P, et al. Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell 2010 ; 141 : 656–67.
Papinski D, Schuschnig M, Reiter W, et al. Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase. Mol Cell 2014 ; 53 : 471–83.
Reggiori F, Tooze SA. Autophagy regulation through Atg9 traffic. J Cell Biol 2012 ; 198 : 151–3.
Puri C, Renna M, Bento CF, et al. ATG16L1 meets ATG9 in recycling endosomes: additional roles for the plasma membrane and endocytosis in autophagosome biogenesis. Autophagy 2014 ; 10 : 182–4.
Feng Y, Backues SK, Baba M, et al. Phosphorylation of Atg9 regulates movement to the phagophore assembly site and the rate of autophagosome formation. Autophagy 2016 ; 12 : 648–58.
Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000 ; 19(5720) : 8.
Tanida I, Ueno T, Kominami E. LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol 2004 ; 36 : 2503–18.
Aparicio IM, Espino J, Bejarano I, et al. Autophagy-related proteins are functionally active in human spermatozoa and may be involved in the regulation of cell survival and motility. Sci Rep 2016 ; 6 : 33647.
Pampliega O, Cuervo AM. Autophagy and primary cilia: dual interplay. Curr Opin Cell Biol 2016 ; 39 : 1–7.
Mann SS, Hammarback JA. Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B. J Neurosci Res 1996 ; 43 : 535–44.
Lamark T, Svenning S, Johansen T. Regulation of selective autophagy: the p62/SQSTM1 paradigm. Essays Biochem 2017 ; 61 : 609–24.
Nakamura S, Yoshimori T. New insights into autophagosome-lysosome fusion. J Cell Sci 2017 ; 130 : 1209–16.
Shang L, Wang X. AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation. Autophagy 2011 ; 7 : 924–6.
Hurley JH, Young LN. Mechanisms of autophagy initiation. Annu Rev Biochem 2017 ; 86 : 225–44.
Demishtein A, Fraiberg M, Berko D, et al. SQSTM1/p62-mediated autophagy compensates for loss of proteasome polyubiquitin recruiting capacity. Autophagy 2017 ; 13 : 1697–708.
Ji CH, Kwon YT. Crosstalk and interplay between the ubiquitin-proteasome system and autophagy. Mol Cells 2017 ; 40 : 441–9.
Kierszenbaum AL, Rivkin E, Tres LL. Molecular biology of sperm head shaping. Soc Reprod Fertil Suppl 2007 ; 65(33) : 43.
Wang H, Wan H, Li X, et al. Atg7 is required for acrosome biogenesis during spermatogenesis in mice. Cell Res 2014 ; 24 : 852–69.
Liu C, Song Z, Wang L, et al. Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice. Development 2017 ; 144 : 441–51.
Zhuo C, Ji Y, Chen Z, et al. Proteomics analysis of autophagy-deficient Atg7
Shang Y, Wang H, Jia P, et al. Autophagy regulates spermatid differentiation via degradation of PDLIM1. Autophagy 2016 ; 12 : 1575–92.
Ravel C, Jaillard S. The Sertoli cell. Morphol Bull Assoc Anat 2011 ; 95 : 151–8.
Liu C, Wang H, Shang Y, et al. Autophagy is required for ectoplasmic specialization assembly in Sertoli cells. Autophagy 2016 ; 12 : 814–32.
Zheng H, Stratton CJ, Morozumi K, et al. Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertility. Proc Natl Acad Sci USA 2007 ; 104 : 6852–7.
Song WH, Yi YJ, Sutovsky M, et al. Autophagy and ubiquitin-proteasome system contribute to sperm mitophagy after mammalian fertilization. Proc Natl Acad Sci USA 2016 ; 113 : E5261–70.
Al Rawi S, Louvet-Vallée S, Djeddi A, et al. Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission. Science 2011 ; 334 : 1144–7.
Singh R, Kaushik S, Wang Y, et al. Autophagy regulates lipid metabolism. Nature 2009 ; 458 : 1131–5.
Ma Y, Zhou Y, Zhu YC, et al. Lipophagy contributes to testosterone biosynthesis in male rat Leydig cells. Endocrinology 2018 ; 159 : 1119.
Yang W, Li L, Huang X, et al. Levels of Leydig cell autophagy regulate the fertility of male naked mole-rats. Oncotarget 2017 ; 8 : 98677–90.
Thelen AM, Zoncu R. Emerging roles for the lysosome in lipid metabolism. Trends Cell Biol 2017 ; 27 : 833–50.
Yefimova MG, Buschiazzo A, Burel A, et al. Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa. Asian J Androl 2019 Apr 24. doi: 10.4103/aja.aja_12_19.
Mu Y, Yan W-J, Yin T-L, et al. Diet-induced obesity impairs spermatogenesis: a potential role for autophagy. Sci Rep 2017 ; 7 : 43475.
Quan C, Wang C, Duan P, et al. Bisphenol a induces autophagy and apoptosis concurrently involving the Akt/mTOR pathway in testes of pubertal SD rats. Environ Toxicol 2017 ; 32 : 1977–89.
Ravel C, Siffroi J. Recherche des causes d’infertilites masculines a partir des anomalies de l’examen de sperme. In: Chanson P, Young J, eds. Traite d’endocrinologie. Paris : Flammarion Medecine-Sciences, 2007 : 680–8.